Apramycin
Modify Date: 2024-01-11 12:07:17
Apramycin structure
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Common Name | Apramycin | ||
|---|---|---|---|---|
| CAS Number | 37321-09-8 | Molecular Weight | 539.57700 | |
| Density | 1.56 g/cm3 | Boiling Point | 823ºC at 760 mmHg | |
| Molecular Formula | C21H41N5O11 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 451.6ºC | |
Use of ApramycinApramycin(Nebramycin II) is an aminoglycoside antibiotic used in veterinary medicine. IC50 value:Target: Apramycin stands out among aminoglycosides for its mechanism of action which is based on blocking translocation and its ability to bind also to the eukaryotic decoding site despite differences in key residues required for apramycin recognition by the bacterial target. The drug binds in the deep groove of the RNA which forms a continuously stacked helix comprising non-canonical C.A and G.A base pairs and a bulged-out adenine. The binding mode of apramycin at the human decoding-site RNA is distinct from aminoglycoside recognition of the bacterial target, suggesting a molecular basis for the actions of apramycin in eukaryotes and bacteria. |
| Name | apramycin |
|---|---|
| Synonym | More Synonyms |
| Description | Apramycin(Nebramycin II) is an aminoglycoside antibiotic used in veterinary medicine. IC50 value:Target: Apramycin stands out among aminoglycosides for its mechanism of action which is based on blocking translocation and its ability to bind also to the eukaryotic decoding site despite differences in key residues required for apramycin recognition by the bacterial target. The drug binds in the deep groove of the RNA which forms a continuously stacked helix comprising non-canonical C.A and G.A base pairs and a bulged-out adenine. The binding mode of apramycin at the human decoding-site RNA is distinct from aminoglycoside recognition of the bacterial target, suggesting a molecular basis for the actions of apramycin in eukaryotes and bacteria. |
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| Related Catalog | |
| References |
| Density | 1.56 g/cm3 |
|---|---|
| Boiling Point | 823ºC at 760 mmHg |
| Molecular Formula | C21H41N5O11 |
| Molecular Weight | 539.57700 |
| Flash Point | 451.6ºC |
| Exact Mass | 539.28000 |
| PSA | 283.64000 |
| Index of Refraction | 1.657 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| APRAMYCIN |
| el857 |
| EINECS 253-460-1 |
| nebramycinfactor2 |
| el-857/820 |
| apralan |
| ApryMycin |
| ambylan |