Decloxizine

Modify Date: 2024-01-05 14:49:26

Decloxizine structure	Common Name	Decloxizine
	CAS Number	3733-63-9	Molecular Weight	340.459
	Density	1.1±0.1 g/cm3	Boiling Point	472.4±40.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₂₈N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	239.5±27.3 °C

Use of Decloxizine

Decloxizine(UCB-1402; NSC289116) is a histamine 1 receptor antagonist.

Name	2-[2-(4-benzhydrylpiperazin-1-yl)ethoxy]ethanol
Synonym	More Synonyms

Description	Decloxizine(UCB-1402; NSC289116) is a histamine 1 receptor antagonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology

Density	1.1±0.1 g/cm3
Boiling Point	472.4±40.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₈N₂O₂
Molecular Weight	340.459
Flash Point	239.5±27.3 °C
Exact Mass	340.215088
PSA	35.94000
LogP	1.43
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.576

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KK7350000

CHEMICAL NAME :: Ethanol, 2-(2-(4-(diphenylmethyl)-1-piperazinyl)ethoxy)-

CAS REGISTRY NUMBER :: 3733-63-9

BEILSTEIN REFERENCE NO. :: 0306385

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C21-H28-N2-O2

MOLECULAR WEIGHT :: 340.51

WISWESSER LINE NOTATION :: T6N DNTJ AYR&R& D2O2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 840 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,1002,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 103 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,1002,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 47 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,1002,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 470 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,1002,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,1002,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 45 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,1002,1968 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 840 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 9,134,1968

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1120 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 9,134,1968

HS Code	2933599090

N-Benzhydrylpip...

CAS#:841-77-0

2-(2-Chloroetho...

CAS#:628-89-7

Decloxizine

CAS#:3733-63-9

Literature: Takeda Chemical Industries, Ltd. Patent: US6248740 B1, 2001 ;

N-Benzhydrylpip...

CAS#:841-77-0

Decloxizine

CAS#:3733-63-9

Literature: Takeda Chemical Industries, Ltd. Patent: EP1243271 A1, 2002 ;

Precursor 2
CAS#:841-77-0 N-Benzhydrylpip... CAS#:628-89-7 2-(2-Chloroetho...
DownStream 0

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Hydroxydiethylphenamine

Decloxizini hydrochloride

1-(Diphenylmethyl)-4-[2-(2-hydroxyethoxy)ethyl]piperazine

1-Benzhydryl-4-[2-(2-hydroxyethoxy)ethyl]piperazine

2-[2-[4-(diphenylmethyl)-1-piperazinyl]ethoxy]ethanol

Decloxizini

Ethanol, 2-[2-[4- (diphenylmethyl)-1-piperazinyl]ethoxy]-

Decloxizine [INN]

1-Benzhydryl-4-(2-(2-hydroxyethoxy)ethyl)piperazine

Decloxizina [INN-Spanish]

2-{2-[4-(Diphenylmethyl)-1-piperazinyl]ethoxy}ethanol

2-[2-(4-Benzhydryl-piperazino)-aethoxy]-aethanol

2-[2-(4-benzhydryl-piperazino)-ethoxy]-ethanol

2-(2-(4-Benzhydrylpiperazin-1-yl)ethoxy)ethanol

UCB 1402

2-[2-(4-diphenylmethyl-piperazin-1-yl)-ethoxy]-ethanol

4-(diphenylmethyl)-1-[2-(2-hydroxyethoxy)ethyl]piperazine

Decloxizine

2-{2-[4-(Diphenylmethyl)piperazin-1-yl]ethoxy}ethanol

Decloxizinum [INN-Latin]

Ethanol, 2-[2-[4-(diphenylmethyl)-1-piperazinyl]ethoxy]-

DecloxizineHydrochloride

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Decloxizine
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Decloxizine
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: Decloxizine
Price: $100.0/100mg $200.0/500mg $400.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Decloxizine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: C21H28N2O2 Decloxizine 3733-63-9
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Price: $108/50mg

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Decloxizine

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