LY450108

Modify Date: 2024-01-02 18:03:54

LY450108 Structure
LY450108 structure
 Common Name LY450108
CAS Number 376594-67-1 Molecular Weight 396.451
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C19H22F2N2O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LY450108


LY450108 is an alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor potentiator. IC50 value: Target: AMPA receptors mediate most of the excitatory neurotransmission and play a key role in synaptic plasticity in the mammalian central nervous system (CNS). Recent evidence has shown that in addition to modulating fast synaptic plasticity and memory processes, AMPA receptor potentiators alter downstream signalling pathways and may thereby have utility in other CNS disorders.

 Names

Name 3,5-difluoro-N-[4-[(2R)-1-(propan-2-ylsulfonylamino)propan-2-yl]phenyl]benzamide
Synonym More Synonyms

 LY450108 Biological Activity

Description LY450108 is an alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor potentiator. IC50 value: Target: AMPA receptors mediate most of the excitatory neurotransmission and play a key role in synaptic plasticity in the mammalian central nervous system (CNS). Recent evidence has shown that in addition to modulating fast synaptic plasticity and memory processes, AMPA receptor potentiators alter downstream signalling pathways and may thereby have utility in other CNS disorders.
Related Catalog
References

[1]. Simon E Ward1, Benjamin D Bax, Mark Harries. Challenges for and current status of research into positive modulators of AMPA receptors. British Journal of Pharmacology. 2010,160(2):181-190.

[2]. O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets. 2007 May;8(5):603-20.

[3]. Jhee SS, Chappell AS, Zarotsky V, et al. Multiple-dose plasma pharmacokinetic and safety study of LY450108 and LY451395 (AMPA receptor potentiators) and their concentration in cerebrospinal fluid in healthy human subjects. J Clin Pharmacol. 2006 Apr;46(4):424-32.

[4]. Douglas A. Schober, Martin B. Gill, Hong Yu, et al. Transmembrane AMPA Receptor Regulatory Proteins and Cornichon-2 Allosterically Regulate AMPA Receptor Antagonists and Potentiators. The Journal of Biological Chemistry, 286, 13134-13142.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C19H22F2N2O3S
Molecular Weight 396.451
Exact Mass 396.131927
PSA 83.65000
LogP 3.41
Index of Refraction 1.568
Storage condition 2-8℃

 Synonyms

(R)-3,5-difluoro-N-(4-(1-(1-methylethylsulfonamido)propan-2-yl)phenyl)benzamide
QCR-13
CS-1090
Benzamide, 3,5-difluoro-N-[4-[(1R)-1-methyl-2-[[(1-methylethyl)sulfonyl]amino]ethyl]phenyl]-
3,5-Difluoro-N-(4-{(2R)-1-[(isopropylsulfonyl)amino]-2-propanyl}phenyl)benzamide
LY450108
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Chemsrc provides LY450108(CAS#:376594-67-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of LY450108 are included as well.>> amp version: LY450108

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