RO 08-2750
Modify Date: 2024-01-08 13:02:14
RO 08-2750 structure
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Common Name | RO 08-2750 | ||
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| CAS Number | 37854-59-4 | Molecular Weight | 270.243 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C13H10N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RO 08-2750Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 µM. Ro 08-2750 inhibits NGF binding to p75NTR selectively over TRKA[1]. |
| Name | 7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carbaldehyde |
|---|---|
| Synonym | More Synonyms |
| Description | Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 µM. Ro 08-2750 inhibits NGF binding to p75NTR selectively over TRKA[1]. |
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| Related Catalog | |
| Target |
IC50: ~ 1 µM (NGF)[1] |
| In Vitro | Ro 08-2750 binds to the NGF dimer thereby probably inducing a change in its conformation such that NGF cannot bind to p75NTR anymore[2]. Ro 08-2750 (10 nM) completely rescues cells from undergoing NGF-induced SK-N-MC 103 cells death[2]. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Molecular Formula | C13H10N4O3 |
| Molecular Weight | 270.243 |
| Exact Mass | 270.075287 |
| PSA | 97.71000 |
| LogP | -0.81 |
| Index of Refraction | 1.754 |
| Hazard Codes | Xi |
|---|---|
| HS Code | 2933990090 |
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| 7,10-Dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde |
| Benzo[g]pteridine-8-carboxaldehyde, 2,3,4,10-tetrahydro-7,10-dimethyl-2,4-dioxo- |