SI-2

Modify Date: 2024-01-14 18:24:10

SI-2 Structure
SI-2 structure
Common Name SI-2
CAS Number 380537-35-9 Molecular Weight 265.313
Density 1.2±0.1 g/cm3 Boiling Point 459.9±37.0 °C at 760 mmHg
Molecular Formula C15H15N5 Melting Point N/A
MSDS N/A Flash Point 231.9±26.5 °C

 Use of SI-2


SI-2 (EPH-116) is a potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2; selectively reduces cellular protein levels of SRC-3, but not that of CARM-1, blocks MDA-MB-468 cell growth with an IC50 value of 3.4 nM, but spares normal cells; significantly inhibit primary tumor growth and reduce SRC-3 protein levels in a breast cancer mouse model; "first-in-class" compound that targets oncogenic coactivator.

 Names

Name SI-2
Synonym More Synonyms

 SI-2 Biological Activity

Description SI-2 (EPH-116) is a potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2; selectively reduces cellular protein levels of SRC-3, but not that of CARM-1, blocks MDA-MB-468 cell growth with an IC50 value of 3.4 nM, but spares normal cells; significantly inhibit primary tumor growth and reduce SRC-3 protein levels in a breast cancer mouse model; "first-in-class" compound that targets oncogenic coactivator.
References References 1. Song X, et al. Proc Natl Acad Sci U S A. 2016 May 3;113(18):4970-5. 2. Rohira AD, et al. Cancer Res. 2017 Aug 15;77(16):4293-4304. View Related Products by Target Other Targets

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 459.9±37.0 °C at 760 mmHg
Molecular Formula C15H15N5
Molecular Weight 265.313
Flash Point 231.9±26.5 °C
Exact Mass 265.132751
LogP 2.39
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.659
Storage condition 2-8°C

 Safety Information

Hazard Codes Xi

 Synonyms

Ethanone, 1-(2-pyridinyl)-, 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone, (1E)-
(1E)-N-(1-Methyl-1H-benzoimidazol-2-yl)-N'-(1-pyridin-2-yl-ethylidene)-hydrazine
(1E)-1-(2-Pyridinyl)ethanone 1-(1-methyl-1H-benzoimidazol-2-yl)-hydrazone
1-Methyl-2-{(2E)-2-[1-(2-pyridinyl)ethylidene]hydrazino}-1H-benzimidazole
SI-2
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