Name | SI-2 |
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Synonyms |
Ethanone, 1-(2-pyridinyl)-, 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone, (1E)-
(1E)-N-(1-Methyl-1H-benzoimidazol-2-yl)-N'-(1-pyridin-2-yl-ethylidene)-hydrazine (1E)-1-(2-Pyridinyl)ethanone 1-(1-methyl-1H-benzoimidazol-2-yl)-hydrazone 1-Methyl-2-{(2E)-2-[1-(2-pyridinyl)ethylidene]hydrazino}-1H-benzimidazole SI-2 |
Description | SI-2 (EPH-116) is a potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2; selectively reduces cellular protein levels of SRC-3, but not that of CARM-1, blocks MDA-MB-468 cell growth with an IC50 value of 3.4 nM, but spares normal cells; significantly inhibit primary tumor growth and reduce SRC-3 protein levels in a breast cancer mouse model; "first-in-class" compound that targets oncogenic coactivator. |
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References | References 1. Song X, et al. Proc Natl Acad Sci U S A. 2016 May 3;113(18):4970-5. 2. Rohira AD, et al. Cancer Res. 2017 Aug 15;77(16):4293-4304. View Related Products by Target Other Targets |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 459.9±37.0 °C at 760 mmHg |
Molecular Formula | C15H15N5 |
Molecular Weight | 265.313 |
Flash Point | 231.9±26.5 °C |
Exact Mass | 265.132751 |
LogP | 2.39 |
Vapour Pressure | 0.0±1.1 mmHg at 25°C |
Index of Refraction | 1.659 |
Storage condition | 2-8°C |
Hazard Codes | Xi |
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