Top Suppliers:I want be here

  • DC Chemicals Limited
  • China
  • Product Name: SI-2
  • Price: $Inquiry/25mg $Inquiry/100mg $Inquiry/500mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

380537-35-9

380537-35-9 structure
380537-35-9 structure
  • Name: SI-2
  • Chemical Name: SI-2
  • CAS Number: 380537-35-9
  • Molecular Formula: C15H15N5
  • Molecular Weight: 265.313
  • Create Date: 2020-01-11 19:37:33
  • Modify Date: 2024-01-14 18:24:10
  • SI-2 (EPH-116) is a potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2; selectively reduces cellular protein levels of SRC-3, but not that of CARM-1, blocks MDA-MB-468 cell growth with an IC50 value of 3.4 nM, but spares normal cells; significantly inhibit primary tumor growth and reduce SRC-3 protein levels in a breast cancer mouse model; "first-in-class" compound that targets oncogenic coactivator.

Name SI-2
Synonyms Ethanone, 1-(2-pyridinyl)-, 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone, (1E)-
(1E)-N-(1-Methyl-1H-benzoimidazol-2-yl)-N'-(1-pyridin-2-yl-ethylidene)-hydrazine
(1E)-1-(2-Pyridinyl)ethanone 1-(1-methyl-1H-benzoimidazol-2-yl)-hydrazone
1-Methyl-2-{(2E)-2-[1-(2-pyridinyl)ethylidene]hydrazino}-1H-benzimidazole
SI-2
Description SI-2 (EPH-116) is a potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2; selectively reduces cellular protein levels of SRC-3, but not that of CARM-1, blocks MDA-MB-468 cell growth with an IC50 value of 3.4 nM, but spares normal cells; significantly inhibit primary tumor growth and reduce SRC-3 protein levels in a breast cancer mouse model; "first-in-class" compound that targets oncogenic coactivator.
References References 1. Song X, et al. Proc Natl Acad Sci U S A. 2016 May 3;113(18):4970-5. 2. Rohira AD, et al. Cancer Res. 2017 Aug 15;77(16):4293-4304. View Related Products by Target Other Targets
Density 1.2±0.1 g/cm3
Boiling Point 459.9±37.0 °C at 760 mmHg
Molecular Formula C15H15N5
Molecular Weight 265.313
Flash Point 231.9±26.5 °C
Exact Mass 265.132751
LogP 2.39
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.659
Storage condition 2-8°C
Hazard Codes Xi