Specnuezhenide

Modify Date: 2024-01-02 11:18:43

Specnuezhenide Structure
Specnuezhenide structure
Common Name Specnuezhenide
CAS Number 39011-92-2 Molecular Weight 686.655
Density 1.5±0.1 g/cm3 Boiling Point 893.8±65.0 °C at 760 mmHg
Molecular Formula C31H42O17 Melting Point N/A
MSDS N/A Flash Point 282.0±27.8 °C

 Use of Specnuezhenide


Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA)[1].

 Names

Name Nuezhenide
Synonym More Synonyms

 Specnuezhenide Biological Activity

Description Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA)[1].
Related Catalog
In Vitro Specnuezhenide (0.2-5.0 μg/mL) significantly decreases the mRNA expression of VEGFA induced by CoCl2 as a dose-dependent manner in ARPE-19 cells[2].
References

[1]. Ma C, et al. Specnuezhenide Decreases Interleukin-1β-Induced Inflammation in Rat Chondrocytes and Reduces Joint Destruction in Osteoarthritic Rats.Front Pharmacol. 2018 Jun 28;9:700.

[2]. Wu J, et al. Inhibition of Hypoxia-Induced Retinal Angiogenesis by Specnuezhenide, an Effective Constituent of Ligustrum lucidum Ait., through Suppression of the HIF-1α/VEGF Signaling Pathway.Molecules. 2016 Dec 21;21(12). pii: E1756.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 893.8±65.0 °C at 760 mmHg
Molecular Formula C31H42O17
Molecular Weight 686.655
Flash Point 282.0±27.8 °C
Exact Mass 686.242188
PSA 260.59000
LogP -0.31
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.636

 Safety Information

Safety Phrases 24/25
HS Code 29389090

 Synonyms

Specnuezhenide
2-(4-Hydroxyphenyl)ethyl 6-O-{[(2S,3E,4S)-3-ethylidene-2-(β-D-glucopyranosyloxy)-5-(methoxycarbonyl)-3,4-dihydro-2H-pyran-4-yl]acetyl}-β-D-glucopyranoside
β-D-Glucopyranoside, 2-(4-hydroxyphenyl)ethyl, 6-[2-[(2S,3E,4S)-3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-yl]acetate]
β-D-Glucopyranoside, 2-(4-hydroxyphenyl)ethyl, 6-[2-[(2S,3Z,4S)-3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-yl]acetate]
2-(4-Hydroxyphenyl)ethyl 6-O-{[(2S,3Z,4S)-3-ethylidene-2-(β-D-glucopyranosyloxy)-5-(methoxycarbonyl)-3,4-dihydro-2H-pyran-4-yl]acetyl}-β-D-glucopyranoside
Specneuzhenide
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