5,6-DIHYDROXY-2-THIOPHEN-2-YL-PYRIMIDINE-4-CARBOXYLIC ACID METHYL ESTER structure
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Common Name | 5,6-DIHYDROXY-2-THIOPHEN-2-YL-PYRIMIDINE-4-CARBOXYLIC ACID METHYL ESTER | ||
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CAS Number | 391680-92-5 | Molecular Weight | 252.24700 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C10H8N2O4S | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of 5,6-DIHYDROXY-2-THIOPHEN-2-YL-PYRIMIDINE-4-CARBOXYLIC ACID METHYL ESTERpUL89 Endonuclease-IN-1 (Compound 13d) is a potent inhibitor of human cytomegalovirus (HCMV) pUL89 endonuclease with the IC50 value of 0.88 μM and has antiviral activitiy[1]. |
Name | methyl 5-hydroxy-4-oxo-2-thiophen-2-yl-1H-pyrimidine-6-carboxylate |
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Synonym | More Synonyms |
Description | pUL89 Endonuclease-IN-1 (Compound 13d) is a potent inhibitor of human cytomegalovirus (HCMV) pUL89 endonuclease with the IC50 value of 0.88 μM and has antiviral activitiy[1]. |
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Related Catalog | |
Target |
IC50:0.88μM (pUL89-C) |
In Vitro | pUL89 Endonuclease-IN-1 (compound 13d) is strongly inhibited pUL89-C with the values of IC500.88μM. pUL89 Endonuclease-IN-1 reveals excellent aqueous solubility, plasma stability, and metabolic stability in vitro ADME. pUL89 Endonuclease-IN-1 displays moderately permeability in the PAMPA[1]. Cell Cytotoxicity Assay[1] Cell Line: HFF cells Concentration: 5 μM Incubation Time: 168 h Result: Showed significant inhibition for HCMV at 5 μM. |
References |
Molecular Formula | C10H8N2O4S |
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Molecular Weight | 252.24700 |
Exact Mass | 252.02000 |
PSA | 120.52000 |
LogP | 0.99060 |
~% 5,6-DIHYDROXY-2... CAS#:391680-92-5 |
Literature: Pace, Paola; Di Francesco, M. Emilia; Gardelli, Cristina; Harper, Steven; Muraglia, Ester; Nizi, Emanuela; Orvieto, Federica; Petrocchi, Alessia; Poma, Marco; Rowley, Michael; Scarpelli, Rita; Laufer, Ralph; Paz, Odalys Gonzalez; Monteagudo, Edith; Bonelli, Fabio; Hazuda, Daria; Stillmock, Kara A.; Summa, Vincenzo Journal of Medicinal Chemistry, 2007 , vol. 50, # 9 p. 2225 - 2239 |
~% 5,6-DIHYDROXY-2... CAS#:391680-92-5 |
Literature: Koch, Uwe; Attenni, Barbara; Malancona, Savina; Colarusso, Stefania; Conte, Immacolata; Di Filippo, Marcello; Harper, Steven; Pacini, Barbara; Giomini, Claudia; Thomas, Steven; Incitti, Ilario; Tomei, Licia; De Francesco, Raffaele; Altamura, Sergio; Matassa, Victor G.; Narjes, Frank Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1693 - 1705 |
~% 5,6-DIHYDROXY-2... CAS#:391680-92-5 |
Literature: Koch, Uwe; Attenni, Barbara; Malancona, Savina; Colarusso, Stefania; Conte, Immacolata; Di Filippo, Marcello; Harper, Steven; Pacini, Barbara; Giomini, Claudia; Thomas, Steven; Incitti, Ilario; Tomei, Licia; De Francesco, Raffaele; Altamura, Sergio; Matassa, Victor G.; Narjes, Frank Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1693 - 1705 |
~14% 5,6-DIHYDROXY-2... CAS#:391680-92-5 |
Literature: Summa, Vincenzo; Petrocchi, Alessia; Matassa, Victor G.; Gardelli, Cristina; Muraglia, Ester; Rowley, Michael; Paz, Odalys Gonzalez; Laufer, Ralph; Monteagudo, Edith; Pace, Paola Journal of Medicinal Chemistry, 2006 , vol. 49, # 23 p. 6646 - 6649 |
5,6-Dihydroxy-2-thiophen-2-yl-pyrimidine-4-carboxylic acid methyl ester |
methyl 5,6-dihydroxy-2-thien-2-ylpyrimidine-4-carboxylate |
4-Pyrimidinecarboxylic acid,5,6-dihydroxy-2-(2-thienyl)-,methyl ester |
methyl 2-(2-thienyl)-4,5-dihydroxypyrimidine-6-carboxylate |
(6E)-6-[hydroxy(methoxy)methylidene]-2-thiophen-2-yl-1H-pyrimidine-4,5-dione |