neamine
Modify Date: 2024-01-06 15:05:44
neamine structure
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Common Name | neamine | ||
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| CAS Number | 3947-65-7 | Molecular Weight | 322.358 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 577.9±50.0 °C at 760 mmHg | |
| Molecular Formula | C12H26N4O6 | Melting Point | 225.5°C (rough estimate) | |
| MSDS | N/A | Flash Point | 303.3±30.1 °C | |
Use of neamineNeamine is a non-toxic derivative derivative of Neomycin and is a broad-spectrum aminoglycoside antibiotic. Neamine is an anti-angiogenesis agent targeting angiogenin. Neamine has potent antibacterial, antitumor and neuroprotective activities[1][2]. |
| Name | neamine |
|---|---|
| Synonym | More Synonyms |
| Description | Neamine is a non-toxic derivative derivative of Neomycin and is a broad-spectrum aminoglycoside antibiotic. Neamine is an anti-angiogenesis agent targeting angiogenin. Neamine has potent antibacterial, antitumor and neuroprotective activities[1][2]. |
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| Related Catalog | |
| In Vitro | Neamine (0.625-25 μM; 48 hours; AsPC-1 cells) treatment inhibits ANG-mediated AsPC-1 cell proliferation in a dose-dependent manner in the range of 0.625-25 μM[1]. Neamine (100 μM) also blocks the nuclear translocation of ANG effectively[1]. Cell Proliferation Assay[1] Cell Line: AsPC-1 cells Concentration: 0.625 µM, 1.25 µM, 2.5 µM, 5 µM, 10 µM, 25 µM Incubation Time: 48 hours Result: Inhibited angiogenin (ANG)-induced AsPC-1 cells proliferation. |
| In Vivo | Neamine (30-60 mg/kg; subcutaneous injection; daily; for 14 days; male Balb/c nude mice) has anti-tumor effects on AsPC-1 xenograft models. Neamine reduces the expression levels of ANG, Ki-67 and CD31 in tumor xenografts[1]. Animal Model: Male Balb/c nude mice (4 weeks old) injected with AsPC-1 cells[1] Dosage: 30 mg/kg, 60 mg/kg Administration: Subcutaneous injection; daily; for 14 days Result: Had anti-tumor effects on AsPC-1 xenograft models. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 577.9±50.0 °C at 760 mmHg |
| Melting Point | 225.5°C (rough estimate) |
| Molecular Formula | C12H26N4O6 |
| Molecular Weight | 322.358 |
| Flash Point | 303.3±30.1 °C |
| Exact Mass | 322.185242 |
| PSA | 203.46000 |
| LogP | -2.78 |
| Vapour Pressure | 0.0±3.6 mmHg at 25°C |
| Index of Refraction | 1.649 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Hazard Codes | T |
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CuAAC-mediated diversification of aminoglycoside-arginine conjugate mimics by non-reducing di- and trisaccharides.
Carbohydr. Res. 371 , 61-7, (2013) Di- and triguanidinylation of trehalose, sucrose, and melizitose has been achieved via a Huisgen-cycloaddition approach. They can serve as aminoglycoside-arginine conjugate mimics, which has been demo... |
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Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.
J. Virol. 87(21) , 11806-20, (2013) Angiogenin (ANG) is a 14-kDa multifunctional proangiogenic secreted protein whose expression level correlates with the aggressiveness of several tumors. We observed increased ANG expression and secret... |
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Investigation of RNA-ligand interactions by 19F NMR spectroscopy using fluorinated probes.
Angew. Chem. Int. Ed. Engl. 51(38) , 9530-4, (2012)
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| (1R,2R,3S,4R,6S)-4,6-Diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-α-D-glucopyranoside |
| 2-Deoxy-4-O-(2,6-diamine-2,6-dideoxy-α-D-glucopyranosyl)-D-streptamine |
| U-5214 |
| α-D-Glucopyranoside, (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy- |
| Neomycin A |
| Negamicin |
| dekamycinv |
| Neamine |
| neomycina |
| (2R,3S,4R,5R,6R)-6-((1R,2R,3S,4R,6S)-4,6-DIAMINO-2,3-DIHYDROXYCYCLOHEXYLOXY)-5-AMINO-2-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-3,4-DIOL |
| 2-Deoxy-4-O-(2,6-diamino-2,6-dideoxy-a-D-glucopyranosyl)-D-streptamine |
| neamin |
| (1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL |
| nebramycinx |