Taxiresinol

Modify Date: 2024-01-20 13:24:52

Taxiresinol Structure
Taxiresinol structure
Common Name Taxiresinol
CAS Number 40951-69-7 Molecular Weight 346.37
Density 1.3±0.1 g/cm3 Boiling Point 590.3±50.0 °C at 760 mmHg
Molecular Formula C19H22O6 Melting Point N/A
MSDS N/A Flash Point 310.8±30.1 °C

 Use of Taxiresinol


Taxiresinol is an orally active and potent lignan, that can be isolated from the heartwood of Taxus baccata. Taxiresinol shows significant antinociceptive activity[1].

 Names

Name 4-[4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-(hydroxymethyl)oxolan-2-yl]benzene-1,2-diol
Synonym More Synonyms

 Taxiresinol Biological Activity

Description Taxiresinol is an orally active and potent lignan, that can be isolated from the heartwood of Taxus baccata. Taxiresinol shows significant antinociceptive activity[1].
Related Catalog
In Vivo Taxiresinol (100 mg/kg,口服,一次) 对对苯醌(p-benzoquinone)诱导的小鼠腹部收缩表现出显著的镇痛作用[1]。 Animal Model: Male Swiss albino mice (20-25 g)[1] Dosage: 100 mg/kg Administration: Oral administration, sixty minutes after the oral administration of test sample, the mice were intraperitoneally injected with 0.1 ml/10 g body weight of 2.5% (v/v) p-benzoquinone solution in distilled H2O. Result: Showed significant antinociceptive activity against p-benzoquinone-induced abdominal contractions (writhing movements) in mice, with a inhibitory ratio of 37.8%.
References

[1]. Küpeli E, et al. Anti-inflammatory and antinociceptive activity of taxoids and lignans from the heartwood of Taxus baccata L. J Ethnopharmacol. 2003 Dec;89(2-3):265-70.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 590.3±50.0 °C at 760 mmHg
Molecular Formula C19H22O6
Molecular Weight 346.37
Flash Point 310.8±30.1 °C
Exact Mass 346.141632
PSA 99.38000
LogP 1.33
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.627

 Safety Information

Hazard Codes Xi

 Synonyms

1,2-Benzenediol, 4-[(2S,3R,4R)-tetrahydro-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-(hydroxymethyl)-2-furanyl]-
4-[(2S,3R,4R)-4-(4-Hydroxy-3-methoxybenzyl)-3-(hydroxymethyl)tetrahydro-2-furanyl]-1,2-benzenediol
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