Timosaponin A3

Modify Date: 2024-01-04 10:58:40

Timosaponin A3 Structure
Timosaponin A3 structure
 Common Name Timosaponin A3
CAS Number 41059-79-4 Molecular Weight 740.918
Density 1.4±0.1 g/cm3 Boiling Point 862.8±65.0 °C at 760 mmHg
Molecular Formula C39H64O13 Melting Point N/A
MSDS N/A Flash Point 475.6±34.3 °C

 Use of Timosaponin A3


Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC50 of 35.4 μM.

 Names

Name Timosaponin A-III
Synonym More Synonyms

 Timosaponin A3 Biological Activity

Description Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC50 of 35.4 μM.
Related Catalog
Target

IC50: 35.4 μM (AChE)[1].

In Vitro Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC50 of 35.4 μM[1]. Timosaponin AIII is identified as a major selective cytotoxic activity in BN108, and its selective cytotoxic activity involves inhibition of mTOR, induction of ER stress and protective autophagy[2].
In Vivo Of the tested steroidal saponins, Timosaponin AIII (TA3) most potently improves memory deficits. Timosaponin AIII increases the scopolamine-induced reduction in step-through latency by 17% (10 mg/kg), 28% (20 mg/kg), and 43% (40 mg/kg). During the acquisition trial, no differences in latent time are observed. Timosaponin AIII (20, 40 mg/kg, p.o.) potently inhibits this reduction of acetylcholine in scopolamine-treated mouse brain. The inhibitory effect of Timosaponin AIII is comparable to that of tacrine, which is used as a positive control[1].
Animal Admin Mice[1] Male ICR mice weighing 28-30 g are used. For the acquisition trial, mice are initially placed in the illuminated compartment and the door between the two compartments is opened 10 s later. Each group contains ten mice. One hour or 5 h before the acquisition trial, mice receive each test agent (e.g., Timosaponin AIII 10, 20 or 40 mg/kg, p.o. ). One hour before the acquisition trial, mice receive tacrine (10 mg/kg, p.o.) as a positive control. Memory impairment is induced by scopolamine treatment (1 mg/kg, i.p.) 0.5 h or 4.5 h after the administration of test agents, tacrine, or 10% Tween 80 solution. Control animals are administered 10% Tween 80 solution alone. Twenty-four hours after the acquisition trial, the mice are again placed in the illuminated compartment for retention trials. The time taken for a mouse to enter the dark compartment after the door opened is measured as the latency time in both acquisition and retention trials, with a maximum of 300 s[1].
References

[1]. Lee B, et al. Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice. Pharmacol Biochem Behav. 2009 Aug;93(2):121-7.

[2]. King FW, et al. Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress. PLoS One. 2009 Sep 30;4(9):e7283.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 862.8±65.0 °C at 760 mmHg
Molecular Formula C39H64O13
Molecular Weight 740.918
Flash Point 475.6±34.3 °C
Exact Mass 740.434692
PSA 196.99000
LogP 3.94
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.606

 Safety Information

Hazard Codes Xn

 Synthetic Route

sarsasapogenyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl-(1->2)-3,4,6-tri-O-acetyl-β-D-galactopyranoside structure

sarsasapogenyl ...

CAS#:107800-07-7

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Timosaponin A3 Structure

Timosaponin A3

CAS#:41059-79-4

Literature: Kintya, P. K.; Shvets, S. A. Chemistry of Natural Compounds, 1984 , vol. 20, p. 575 - 578 Khimiya Prirodnykh Soedinenii, 1984 , # 5 p. 610 - 614

 Precursor & DownStream

Precursor  1

DownStream  0

 Synonyms

Timosaponin A3
XilingsaponinA
(3β,5β)-Spirostan-3-yl 2-O-β-D-glucopyranosyl-β-D-galactopyranoside
Filiferin B
β-D-Galactopyranoside, (3β,5β)-spirostan-3-yl 2-O-β-D-glucopyranosyl-
Timosaponina-
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