Neobavaisoflavone

Modify Date: 2024-01-02 20:42:06

Neobavaisoflavone Structure
Neobavaisoflavone structure
 Common Name Neobavaisoflavone
CAS Number 41060-15-5 Molecular Weight 322.354
Density 1.3±0.1 g/cm3 Boiling Point 545.0±50.0 °C at 760 mmHg
Molecular Formula C20H18O4 Melting Point 195-196ºC
MSDS Chinese USA Flash Point 197.7±23.6 °C

 Use of Neobavaisoflavone


Neobavaisoflavone, an isoflavone isolated from Psoralea corylifolia, has striking anti-inflammatory and anti-cancer effects. IC50 value: 42.93 μM (toward CCRF-CEM cells); 114.64 μM [against HCT116 (p53(+/+)) cells] [2]Target:In vitro: In the cancer cells, neobavaisoflavone sensitizes human U373MG glioma cells to TRAIL-mediated apoptosis; upregulated DR5 expression; induced TRAIL-mediated apoptosis in human glioma cells by suppressing migration and invasion, and by inhibiting anoikis resistance [1]. In caner cell lines, neobavaisoflavone is selectively active, and IC50 values below 115 μM were obtained on 6/9 cell lines, with values ranging from 42.93 μM (toward CCRF-CEM cells) to 114.64 μM [against HCT116 (p53(+/+)) cells] [2]. In vivo:

 Names

Name 7-hydroxy-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]chromen-4-one
Synonym More Synonyms

 Neobavaisoflavone Biological Activity

Description Neobavaisoflavone, an isoflavone isolated from Psoralea corylifolia, has striking anti-inflammatory and anti-cancer effects. IC50 value: 42.93 μM (toward CCRF-CEM cells); 114.64 μM [against HCT116 (p53(+/+)) cells] [2]Target:In vitro: In the cancer cells, neobavaisoflavone sensitizes human U373MG glioma cells to TRAIL-mediated apoptosis; upregulated DR5 expression; induced TRAIL-mediated apoptosis in human glioma cells by suppressing migration and invasion, and by inhibiting anoikis resistance [1]. In caner cell lines, neobavaisoflavone is selectively active, and IC50 values below 115 μM were obtained on 6/9 cell lines, with values ranging from 42.93 μM (toward CCRF-CEM cells) to 114.64 μM [against HCT116 (p53(+/+)) cells] [2]. In vivo:
Related Catalog
References

[1]. Kim YJ, et al. Neobavaisoflavone sensitizes apoptosis via the inhibition of metastasis in TRAIL-resistant human glioma U373MG cells. Life Sci. 2014 Jan 30;95(2):101-7.

[2]. Kuete V, Activity of three cytotoxic isoflavonoids from Erythrina excelsa and Erythrina senegalensis (neobavaisoflavone, sigmoidin H and isoneorautenol) toward multi-factorial drug resistant cancer cells. Phytomedicine. 2014 Apr 15;21(5):682-8.

[3]. Ming-Jaw Don, et al. Neobavaisoflavone stimulates osteogenesis via p38-mediated up-regulation of transcription factors and osteoid genes expression in MC3T3-E1 cells. Phytomedicine Volume 19, Issue 6, 15 April 2012, Pages 551–561

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 545.0±50.0 °C at 760 mmHg
Melting Point 195-196ºC
Molecular Formula C20H18O4
Molecular Weight 322.354
Flash Point 197.7±23.6 °C
Exact Mass 322.120514
PSA 70.67000
LogP 4.87
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.645

 Safety Information

RIDADR NONH for all modes of transport
RTECS DJ3100028

 Synonyms

neobavaisoflavone
4H-1-Benzopyran-4-one, 7-hydroxy-3-[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-
7-Hydroxy-3-[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-4H-chromen-4-one
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