CS476

Modify Date: 2024-01-17 18:27:41

Use of CS476

CS476 is a potent hypoglycaemic agent.

Name	N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2,3-dihydro-1-benzofuran-7-carboxamide
Synonym	More Synonyms

Description	CS476 is a potent hypoglycaemic agent.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease
In Vivo	In normal fasting dogs, rabbits, rats and mice the maximal hypoglycaemia produced by intravenous administration of CS476 is comparable on a weight basis to that produced by Glibenclamide. Randomized Latin square experiments in dogs show that 0.03 mg/kg orally of CS476 and of Glibenclamide cause the same maximal decrease of blood glucose and that CS476 has the shorter duration of action. CS476 has no hypoglycaemic effect in totally pancreatectomized dogs nor in streptozotocin diabetic dogs and rats. The insulin releasing activity is studied in dogs after intravenous and oral administration of equipotent doses of CS476, Tolbutamide and Glibenclamide[1].
References	[1]. Jorgensen KD. The pharmacology of a new hypoglycaemic agent N-[4-(2-(2,3-dihydrobenzo(b)furan-m-carboxamido)-ethyl)-benzenesulphonyl]-N'-cyclohexylurea (NOVO CS 476). I. Pharmacological studies on the hypoglycaemic effect. Acta Pharmacol Toxicol (Copenh). 1977 Feb;40(2):216-26.

n-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2,3-dihydro-1-benzofuran-7-carboxamide

NOVO CS 476

N-(2-(4-((((Cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2,3-dihydro-7-benzofurancarboxamide

CS-476

CS476

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