TIC10 Analogue
Modify Date: 2024-01-05 01:20:16
TIC10 Analogue structure
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Common Name | TIC10 Analogue | ||
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| CAS Number | 41276-02-2 | Molecular Weight | 386.489 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 559.7±60.0 °C at 760 mmHg | |
| Molecular Formula | C24H26N4O | Melting Point | N/A | |
| MSDS | USA | Flash Point | 292.3±32.9 °C | |
Use of TIC10 AnalogueTIC10 isomer is the isomer of TIC10. TIC10 isomer does not possess the reported biological activity of inducing TRIAL expression. |
| Name | tic 10 |
|---|---|
| Synonym | More Synonyms |
| Description | TIC10 isomer is the isomer of TIC10. TIC10 isomer does not possess the reported biological activity of inducing TRIAL expression. |
|---|---|
| Related Catalog | |
| In Vitro | TRAIL (TNF related apoptosis inducing ligand) is a cytokine that kills cancer cells but shows no toxicity against normal cells. Active pharmaceutical ingredient TIC-10 (TRAIL inducing compound 10) (Compound 3a), is an anticancer drug first reported in a 1973 patent. The structure of TIC10 3a had been mis-assigned as TIC10 isomer (Compound 3b) in the initial patent. Subsequent synthesis of the originally reported structure by an alternate route shows TIC10 isomer (Compound 3b) does not possess the reported biological activity of inducing TRIAL expression[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 559.7±60.0 °C at 760 mmHg |
| Molecular Formula | C24H26N4O |
| Molecular Weight | 386.489 |
| Flash Point | 292.3±32.9 °C |
| Exact Mass | 386.210663 |
| PSA | 42.53000 |
| LogP | 3.19 |
| Appearance of Characters | white to beige |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.672 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: soluble2mg/mL, clear (warmed) |
| RIDADR | NONH for all modes of transport |
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Pharmacophore reassignment for induction of the immunosurveillance cytokine TRAIL.
Angew. Chem. Int. Ed. Engl. , doi:10.1002/anie.201402133, (2014) Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is an immunosurveillance cytokine that kills cancer cells but demonstrates little toxicity against normal cells. While investigati... |
| Imidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3H)-one, 2,6,7,8,9,10-hexahydro-10-[(2-methylphenyl)methyl]-7-(phenylmethyl)- |
| Potent Akt/ERK inhibitor |
| 7-benzyl-10-(2-methylbenzyl)-2,3,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(10H)-one |
| 7-Benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3H)-one |
| TIC10 - Isomer |
| TIC10 isomer |