8-Cl-cAMP
Modify Date: 2024-01-12 15:16:25
8-Cl-cAMP structure
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Common Name | 8-Cl-cAMP | ||
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| CAS Number | 41941-56-4 | Molecular Weight | 363.65100 | |
| Density | 2.55 g/cm3 | Boiling Point | 731.7ºC | |
| Molecular Formula | C10H11ClN5O6P | Melting Point | N/A | |
| MSDS | USA | Flash Point | 396.3ºC | |
Use of 8-Cl-cAMP8-Chloro-cAMP is a cAMP analogue that induces growth arrest, and modulates cAMP-dependent PKA activity. 8-Chloro-cAMP has anticancer activity[1]. |
| Name | 8-chloro-camp |
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| Synonym | More Synonyms |
| Description | 8-Chloro-cAMP is a cAMP analogue that induces growth arrest, and modulates cAMP-dependent PKA activity. 8-Chloro-cAMP has anticancer activity[1]. |
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| Related Catalog | |
| In Vitro | 8-Chloro-cAMP markedly inhibits vascular smooth muscle cell (VSMC) proliferation in vitro, reduces protein kinase A (PKA) RIα subunit expression, and induces PKA RIIβ subunit expression[1]. |
| In Vivo | In rat bearing balloon injury, 8-Chloro-cAMP (12 mg/kg) reduces, in a dose-dependent manner, neointimal area and neointima/media ratio after balloon injury. 8-Chloro-cAMP shows a reduction of proliferative activity of VSMCs in vivo[1]. |
| References |
| Density | 2.55 g/cm3 |
|---|---|
| Boiling Point | 731.7ºC |
| Molecular Formula | C10H11ClN5O6P |
| Molecular Weight | 363.65100 |
| Flash Point | 396.3ºC |
| Exact Mass | 363.01400 |
| PSA | 164.65000 |
| LogP | 0.41720 |
| Index of Refraction | 2.009 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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Involvement of Akt2/protein kinase B β (PKBβ) in the 8-Cl-cAMP-induced cancer cell growth inhibition.
J. Cell Physiol. 228(4) , 890-902, (2013) 8-chloro-cyclic AMP (8-Cl-cAMP), which induces differentiation, growth inhibition, and apoptosis in various cancer cells, has been investigated as a putative anti-cancer drug. However, the exact mecha... |
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Glucagon stimulates ghrelin secretion through the activation of MAPK and EPAC and potentiates the effect of norepinephrine.
Endocrinology 154(2) , 666-74, (2013) Ghrelin is a stomach-derived orexigenic hormone whose levels in circulation are altered by energy availability. Like ghrelin, the glucotropic hormone glucagon increases in the fasting state and serves... |
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The cAMP analogs have potent anti-proliferative effects on medullary thyroid cancer cell lines.
Endocrine 51 , 101-12, (2016) The oncogenic activation of the rearranged during transfection (RET) proto-oncogene has a main role in the pathogenesis of medullary thyroid cancer (MTC). Several lines of evidence suggest that RET fu... |
| 8-chloroadenosine 3',5'-cyclic-monophosphate |
| Tocladesine |
| 8-chloro-O3',O5'-hydroxyphosphoryl-adenosine |
| 8-CL-CAMP |
| MFCD00153938 |
| 8-chloro-cyclicadenosinemonophosphate |
| 8-chlorocyclicamp |
| 8-chloroadenosine 3',5'-monophosphate |