Transketolase-IN-4

Modify Date: 2024-02-02 00:35:58

Transketolase-IN-4 Structure
Transketolase-IN-4 structure
Common Name Transketolase-IN-4
CAS Number 419547-73-2 Molecular Weight 335.78700
Density N/A Boiling Point N/A
Molecular Formula C19H14ClN3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Transketolase-IN-4


Transketolase-IN-4 is a potent transketolase inhibitor (IC50=3.9 μM). Transketolase-IN-4 inhibits tumor cell proliferation of SW620, LS174T, and MIA PaCa-2. Transketolase-IN-4 is a possible Mycobacterium tuberculosis DXS inhibitor, with an IC50 value of 114.1 μM[1][2].

 Names

Name 3-(4-chlorophenyl)-5-benzyl-4H-pyrazolo[1,5-a]pyrimidin-7-one

 Transketolase-IN-4 Biological Activity

Description Transketolase-IN-4 is a potent transketolase inhibitor (IC50=3.9 μM). Transketolase-IN-4 inhibits tumor cell proliferation of SW620, LS174T, and MIA PaCa-2. Transketolase-IN-4 is a possible Mycobacterium tuberculosis DXS inhibitor, with an IC50 value of 114.1 μM[1][2].
Related Catalog
Target

IC50: 3.9 μM (Transketolase)[1]; 114.1 μM (Mycobacterium tuberculosis DXS)[2]

References

[1]. Du MX, et al. Identification of novel small-molecule inhibitors for human transketolase by high-throughput screening with fluorescent intensity (FLINT) assay. J Biomol Screen. 2004 Aug;9(5):427-33.  

[2]. Mao J, et al. Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5320-3.  

 Chemical & Physical Properties

Molecular Formula C19H14ClN3O
Molecular Weight 335.78700
Exact Mass 335.08300
PSA 50.16000
LogP 3.93380