d [Leu4,Lys8] -VP TFA

Modify Date: 2024-01-05 10:13:56

d [Leu4,Lys8] -VP TFA structure	Common Name	d [Leu4,Lys8] -VP TFA
	CAS Number	42061-33-6	Molecular Weight	1026.23000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₇H₆₇N₁₁O₁₁S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of d [Leu4,Lys8] -VP TFA

D[LEU4,LYS8]-VP is a selective agonist of vasopressin V1b receptor, with the Kis of 0.16 nM, 0.52 nM, and 0.1.38 nM for rat, human and mouse V1b receptor, respectively. D[LEU4,LYS8]-VP has weak antidiuretic, vasopressor, and in vitro oxytocic activities[1][2].

Name	d[Leu4,Lys8]-VP
Synonym	More Synonyms

Description	D[LEU4,LYS8]-VP is a selective agonist of vasopressin V1b receptor, with the Kis of 0.16 nM, 0.52 nM, and 0.1.38 nM for rat, human and mouse V1b receptor, respectively. D[LEU4,LYS8]-VP has weak antidiuretic, vasopressor, and in vitro oxytocic activities[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor Research Areas >> Neurological Disease
Target	vasopressin V1b receptor[1]
References	[1]. Ana P, et, al. Pharmacological and physiological characterization of d[Leu4, Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology. 2007 Sep; 148(9): 4136-46. [2]. Ana P, et, al. Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8. J Med Chem. 2007 Feb 22; 50(4): 835-47.