ACTH (11-24)

Modify Date: 2024-01-07 11:52:03

ACTH (11-24) Structure
ACTH (11-24) structure
Common Name ACTH (11-24)
CAS Number 4237-93-8 Molecular Weight 1652.04
Density N/A Boiling Point N/A
Molecular Formula C77H134N24O16 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ACTH (11-24)


ACTH (11-24) is a fragment of adrenocorticotrophin, acts as an antagonist of adrenocorticotropic hormone (ACTH) receptor, and induces cortisol release.

 Names

Name Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro
Synonym More Synonyms

 ACTH (11-24) Biological Activity

Description ACTH (11-24) is a fragment of adrenocorticotrophin, acts as an antagonist of adrenocorticotropic hormone (ACTH) receptor, and induces cortisol release.
Related Catalog
Target

Adrenocorticotropic hormone receptor[1]

In Vitro ACTH (11-24) acts as an antagonist of adrenocorticotropic hormone receptor[1]. ACTH (11-24) induces cortisol secretion submaximally in freshly dispersed or cultured beef adrenal cortical cells. The maximal cortisol release by ACTH (11-24) is enhanced by forskolin but inhibited by calcium channel blockers[2].
In Vivo ACTH (11-24) blocks electroacupuncture (EA) anti-edema but not EA anti-hyperalgesia in rats[1].
References

[1]. Li ZG, et al. Adrenocorticotropin(1-10) and -(11-24) promote adrenal steroidogenesis by different mechanisms. Endocrinology. 1989 Aug;125(2):592-6.

[2]. Li A, et al. Electroacupuncture activates corticotrophin-releasing hormone-containing neurons in the paraventricular nucleus of the hypothalammus to alleviate edema in a rat model of inflammation. BMC Complement Altern Med. 2008 May 12;8:20.

 Chemical & Physical Properties

Molecular Formula C77H134N24O16
Molecular Weight 1652.04
PSA 649.37000
LogP 4.81050
Storage condition 2-8℃

 Synonyms

acth (11-24)