1-benzylimidazole

Modify Date: 2024-01-04 13:52:38

1-benzylimidazole Structure
1-benzylimidazole structure
 Common Name 1-benzylimidazole
CAS Number 4238-71-5 Molecular Weight 158.20
Density 1.0±0.1 g/cm3 Boiling Point 310.0±11.0 °C at 760 mmHg
Molecular Formula C10H10N2 Melting Point 68-70 °C(lit.)
MSDS Chinese USA Flash Point 141.3±19.3 °C

 Use of 1-benzylimidazole


1-Benzyl-1H-imidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

 Names

Name 1-Benzylimidazole
Synonym More Synonyms

 1-benzylimidazole Biological Activity

Description 1-Benzyl-1H-imidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Related Catalog
In Vitro Benzylimidazole 是一种选择性血栓素合成酶抑制剂和 UDP-葡萄糖醛基转移酶刺激剂。血栓素合成酶是一种细胞色素 P450 酶。细胞色素 P450 蛋白参与催化药物代谢和胆固醇、类固醇和其他脂类合成的许多反应。该酶在一些病理生理过程中起重要作用，包括止血、心血管疾病和中风。该基因表达两种转录变体。1-苯并咪唑选择性抑制血栓博烷合成酶活性。1-苯并咪唑降低大鼠脑缺血再灌注损伤后 TXB2 水平，增加血流量。雄性 Wistar 大鼠经胃给予 1-苯并咪唑 (25、75和100 mg/kg/天) 可引起剂量依赖性肝炎。1-苯并咪唑降低血浆甘油三酯水平 60-70%。1-苯并咪唑刺激三种不同形式的 UDP-葡萄糖醛基转移酶。1-苯并咪唑对 4-甲基菊酮、1-萘酚、吗啡和一种单萜类醇 nopol 的活性显著提高。苯并咪唑呈浓度依赖性增加肝细胞 CYP1A 催化活性和 CYP1A mRNA。
References

[1]. Pettigrew LC, Grotta JC, Rhoades HM, et al. Effect of thromboxane synthase inhibition on eicosanoid levels and blood flow in ischemic rat brain[J]. Stroke, 1989, 20(5): 627-632

[2]. Magdalou J, Totis M, Boiteux-Antoine AF, et al. Effect of 1-benzylimidazole on cytochromes P-450 induction and on the activities of epoxy hydrolases and UDP-glucuronosyltransferases in rat liver[J]. Biochemical pharmacology, 1988, 37(17): 3297-330 Shen RF, Tai H H. Thromboxanes: synthase and receptors[J]. Journal of biomedical science , 1998, 5(3): 153-17

[3]. Shen RF, Tai H H. Thromboxanes: synthase and receptors[J]. Journal of biomedical science, 1998, 5(3): 153-17

[4]. Navas JM, Chana A, Herradón B, et al. Induction of CYP1A by the N‐imidazole derivative, 1‐benzylimidazole[J]. Environmental toxicity and chemistry, 2003, 22(4): 830-83

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 310.0±11.0 °C at 760 mmHg
Melting Point 68-70 °C(lit.)
Molecular Formula C10H10N2
Molecular Weight 158.20
Flash Point 141.3±19.3 °C
Exact Mass 158.084396
PSA 17.82000
LogP 1.46
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.580
Water Solubility insoluble

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2933290090

 Synthetic Route

 Customs

HS Code 2933290090
Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

1-BENZYL IMIDAZOLE
MFCD00005296
Imidazole,1-benzyl
1H-Imidazole, 1-(phenylmethyl)-
1-benzylimidazole
1H-Imidazole, 1- (phenylmethyl)-
BENZYLIMIDAZOLE
1-Benzyl-1H-imidazole
N-benzylimidazole
EINECS 224-200-4
3-Benzylimidazole
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