1,6-Bis(mesyloxy)hexane

Modify Date: 2024-01-05 08:36:37

1,6-Bis(mesyloxy)hexane Structure
1,6-Bis(mesyloxy)hexane structure
Common Name 1,6-Bis(mesyloxy)hexane
CAS Number 4239-24-1 Molecular Weight 274.35500
Density 1.273g/cm3 Boiling Point 474.6ºC at 760 mmHg
Molecular Formula C8H18O6S2 Melting Point N/A
MSDS N/A Flash Point 240.8ºC

 Use of 1,6-Bis(mesyloxy)hexane


16-Bismesyloxyhexane is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

 Names

Name 6-methylsulfonyloxyhexyl methanesulfonate
Synonym More Synonyms

 1,6-Bis(mesyloxy)hexane Biological Activity

Description 16-Bismesyloxyhexane is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog
Target

Cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

 Chemical & Physical Properties

Density 1.273g/cm3
Boiling Point 474.6ºC at 760 mmHg
Molecular Formula C8H18O6S2
Molecular Weight 274.35500
Flash Point 240.8ºC
Exact Mass 274.05400
PSA 103.50000
LogP 2.66080
Index of Refraction 1.471

 Synthetic Route

~92%

1,6-Bis(mesyloxy)hexane Structure

1,6-Bis(mesylox...

CAS#:4239-24-1

Literature: Li, Yi; Hesse, Manfred Helvetica Chimica Acta, 2003 , vol. 86, # 2 p. 310 - 323

 Synonyms

1,6-hexanediyl dimethanesulfonate
Hexane dimethanesulphonate
hexamethylene dimesylate
CTK8I7029
1,6-Bis(mesyloxy)hexane
hexane-1,6-diyl bis[methanesulfonate]
1,6-bis-methanesulfonyloxy-hexane
1,6-hexyl dimesylate
1,6-Hexanediol,dimethanesulfonate
AC1L3RSR
Hexasulphan
1,6-Bis-methansulfonyloxy-hexan
Hexasulfan