CASIN

Modify Date: 2024-01-02 16:26:20

CASIN Structure
CASIN structure
Common Name CASIN
CAS Number 425399-05-9 Molecular Weight 306.401
Density 1.2±0.1 g/cm3 Boiling Point 577.8±50.0 °C at 760 mmHg
Molecular Formula C20H22N2O Melting Point N/A
MSDS USA Flash Point 303.3±30.1 °C

 Use of CASIN


CASIN is a selective GTPase Cdc42 inhibitor with IC50 of 2 uM. In vitro: Treatment with CASIN (5 uM) reduced the elevated level of active Cdc42 observed in aged primitive hematopoietic cells to the level observed in young cells In vivo: Reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs.

 Names

Name CASIN
Synonym More Synonyms

 CASIN Biological Activity

Description CASIN is a selective GTPase Cdc42 inhibitor with IC50 of 2 uM. In vitro: Treatment with CASIN (5 uM) reduced the elevated level of active Cdc42 observed in aged primitive hematopoietic cells to the level observed in young cells In vivo: Reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs.
Related Catalog
References

[1]. Florian MC et al. Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell, 2012 May 4, 10(5):520-30.

[2]. Peterson JR et al. Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 577.8±50.0 °C at 760 mmHg
Molecular Formula C20H22N2O
Molecular Weight 306.401
Flash Point 303.3±30.1 °C
Exact Mass 306.173218
LogP 3.60
Appearance of Characters light yellow solid
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.682
Storage condition -20℃

 Safety Information

RIDADR NONH for all modes of transport

 Synonyms

Ethanol, 2-[(2,3,4,9-tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]-
2-[(6-Phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino]ethanol