NS3694
Modify Date: 2024-01-08 11:24:27
NS3694 structure
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Common Name | NS3694 | ||
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| CAS Number | 426834-38-0 | Molecular Weight | 358.70000 | |
| Density | 1.574g/cm3 | Boiling Point | 378.448ºC at 760 mmHg | |
| Molecular Formula | C15H10ClF3N2O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 182.679ºC | |
Use of NS3694NS3694, a diarylurea compound, is an apoptosome inhibitor. NS3694 inhibits apoptosome formation and caspase activation[1]. |
| Name | 4-chloro-2-[[3-(trifluoromethyl)phenyl]carbamoylamino]benzoic acid |
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| Synonym | More Synonyms |
| Description | NS3694, a diarylurea compound, is an apoptosome inhibitor. NS3694 inhibits apoptosome formation and caspase activation[1]. |
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| Related Catalog | |
| In Vitro | When cell extracts are stimulated with cytochrome c and dATP in the presence of NS3694 (10-100 μM; 120 min), a dose-dependent inhibition of caspase 9, 3, and 7 processing, DFF45/ICAD and PARP cleavage, and DEVDase activity is observed[1]. NS3694 (10-100 μM) inhibits TNF-induced effector caspase activation and apoptosis in MCF-casp3 cells[1]. NS3694 specifically suppresses the cytochrome C-induced formation of apoptosome complex and caspase-9 activation, thus inhibiting the mitochondria-mediated apoptosis. NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase-9[1]. Western Blot Analysis[1] Cell Line: HeLa cells Concentration: 10 μM, 50 μM, 100 μM Incubation Time: 120 min Result: Inhibited cytochrome c- and dATP-induced DEVDase activation and processing of caspases and caspase substrates. |
| References |
| Density | 1.574g/cm3 |
|---|---|
| Boiling Point | 378.448ºC at 760 mmHg |
| Molecular Formula | C15H10ClF3N2O3 |
| Molecular Weight | 358.70000 |
| Flash Point | 182.679ºC |
| Exact Mass | 358.03300 |
| PSA | 78.43000 |
| LogP | 4.84700 |
| Index of Refraction | 1.638 |
| Storage condition | -20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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The novel HDAC inhibitor AR-42-induced anti-colon cancer cell activity is associated with ceramide production.
Biochem. Biophys. Res. Commun. 463 , 545-50, (2015) In the current study, we investigated the potential activity of AR-42, a novel histone deacetylase (HDAC) inhibitor, against colon cancer cells. Our in vitro results showed that AR-42 induced ceramide... |
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An epistatic effect of apaf-1 and caspase-9 on chlamydial infection.
Apoptosis 20 , 1271-80, (2015) Chlamydia is an obligate intracellular bacterial pathogen that replicates solely within a membrane-bound vacuole termed an inclusion. Chlamydia seems to perturb multiple cellular processes of the host... |
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Brucella abortus Induces the Premature Death of Human Neutrophils through the Action of Its Lipopolysaccharide.
PLoS Pathog. 11 , e1004853, (2015) Most bacterial infections induce the activation of polymorphonuclear neutrophils (PMNs), enhance their microbicidal function, and promote the survival of these leukocytes for protracted periods of tim... |
| Apoptosis Inhibitor II,NS3694 |
| NS3694 |