Methyl 5-amino-2-hydroxybenzoate

Modify Date: 2024-01-09 20:31:26

Methyl 5-amino-2-hydroxybenzoate structure	Common Name	Methyl 5-amino-2-hydroxybenzoate
	CAS Number	42753-75-3	Molecular Weight	167.162
	Density	1.3±0.1 g/cm3	Boiling Point	319.2±27.0 °C at 760 mmHg
	Molecular Formula	C₈H₉NO₃	Melting Point	95-99 °C(lit.)
	MSDS	Chinese USA	Flash Point	146.8±23.7 °C
	Symbol	GHS07	Signal Word	Warning

Name	Methyl 5-amino-2-hydroxybenzoate
Synonym	More Synonyms

Density	1.3±0.1 g/cm3
Boiling Point	319.2±27.0 °C at 760 mmHg
Melting Point	95-99 °C(lit.)
Molecular Formula	C₈H₉NO₃
Molecular Weight	167.162
Flash Point	146.8±23.7 °C
Exact Mass	167.058243
PSA	72.55000
LogP	0.56
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.606

Methyl 5-amino-2-hydroxybenzoate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VO1683100

CHEMICAL NAME :: Salicylic acid, 5-amino-, methyl ester

CAS REGISTRY NUMBER :: 42753-75-3

BEILSTEIN REFERENCE NO. :: 2803211

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H9-N-O3

MOLECULAR WEIGHT :: 167.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 61,255,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 61,255,1965

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H317-H319-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn
Risk Phrases	22-36/37/38-43
Safety Phrases	S26
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	VO1683100
HS Code	2922509090

Methanol

CAS#:67-56-1

5-Aminosalicyli...

CAS#:89-57-6

~98%

Methyl 5-amino-...

CAS#:42753-75-3

Literature: Zhou, Lei; Yang, Haishen; Wang, Pengfei Journal of Organic Chemistry, 2011 , vol. 76, # 15 p. 5873 - 5881

Methyl 2-hydrox...

CAS#:17302-46-4

~95%

Methyl 5-amino-...

CAS#:42753-75-3

Literature: Schmidt, Bernd; Hoelter, Frank; Berger, Rene; Jessel, Soenke Advanced Synthesis and Catalysis, 2010 , vol. 352, # 14-15 p. 2463 - 2473

Methanol

CAS#:67-56-1

5-Methylsalicyl...

CAS#:89-56-5

~62%

Methyl 5-amino-...

CAS#:42753-75-3

Literature: Desreumaux, Pierre; Bellinvia, Salvatore; Chavatte, Philippe; Baroni, Sergio Patent: US2011/39808 A1, 2011 ; Location in patent: Page/Page column 50 ;

Sulfuric acid

CAS#:7664-93-9

5-Aminosalicyli...

CAS#:89-57-6

~45%

Methyl 5-amino-...

CAS#:42753-75-3

Literature: DAK-Laboratoriet Patent: US4933330 A1, 1990 ;

5-Aminosalicyli...

CAS#:89-57-6

Methyl 5-amino-...

CAS#:42753-75-3

Literature: American Cyanamid Company Patent: US4087613 A1, 1978 ;

Salicylic acid,...

CAS#:96-97-9

Methyl 5-amino-...

CAS#:42753-75-3

Literature: Erra, Montse; Moreno, Imma; Sanahuja, Jordi; Andres, Miriam; Reinoso, Raquel F.; Lozoya, Estrella; Pizcueta, Pilar; Godessart, Nuria; Castro-Palomino, Julio Cesar Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 24 p. 7268 - 7272

Methyl 3-nitrob...

CAS#:618-95-1

Methyl 5-amino-...

CAS#:42753-75-3

Literature: Gattermann Chemische Berichte, 1894 , vol. 27, p. 1930 Full Text Show Details Bayer and Co. Patent: DE79865 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 4, p. 56

|p|-Aminophenol...

CAS#:51-78-5

Methyl 5-amino-...

CAS#:42753-75-3

Literature: Wessely; Benedikt; Benger Monatshefte fuer Chemie, 1949 , vol. 80, p. 197,199

Precursor 8
CAS#:67-56-1 Methanol CAS#:89-57-6 5-Aminosalicyli... CAS#:17302-46-4 Methyl 2-hydrox... CAS#:89-56-5 5-Methylsalicyl...
CAS#:7664-93-9 Sulfuric acid CAS#:96-97-9 Salicylic acid,... CAS#:618-95-1 Methyl 3-nitrob... CAS#:51-78-5 \|p\|-Aminophenol...
DownStream 4
CAS#:22802-67-1 Methyl 5-amino-... CAS#:104333-09-7 4-Amino-2-(hydr... CAS#:80074-26-6 Benzoicacid, 5-... CAS#:6245-02-9 methyl 5-[[2-(d...

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

[Therapeutic effect of methyl 5-aminosalicylate on experimental ulcerative colitis in rabbits].

Zhongguo Yao Li Xue Bao 11(1) , 54-6, (1990)

Using the improved Kirsner model of ulcerative colitis in rabbits, we found that the therapeutic effect of methyl 5-amino salicylate hydrochloride (M-5-AS) was similar to that of sulfasalazine (salicy...

[Teratologic studies of methyl 5-aminosalicylate and salicylazopyridine].

Zhongguo Yao Li Xue Bao 13(3) , 265-7, (1992)

Methyl 5-aminosalicylate hydrochloride (M-5-AS) at the dosages of 21, 42, 209, and 417 mg.kg-1.d-1 ig to mice during d 6-15 of pregnancy, no obvious effects on the placenta, fetus weight, sex differen...

Benzoic acid, 5-amino-2-hydroxy-, methyl ester

MFCD01317557

Benzoic acid, 5-amino-2-hydroxy-, methyl ester (9CI)

Methyl 5-amino-2-hydroxybenzoate