HQ-415
Modify Date: 2024-01-22 12:10:47
HQ-415 structure
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Common Name | HQ-415 | ||
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| CAS Number | 430462-93-4 | Molecular Weight | 415.484 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 614.9±55.0 °C at 760 mmHg | |
| Molecular Formula | C25H25N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 325.7±31.5 °C | |
Use of HQ-415HQ-415 is a class of clinically relevant bioactive metal chelators related to clioquinol. The effective concentration eliciting a EC50 for HQ-415 is 15 μM. IC50 value: 15 μM (EC50)in vitro: In TDP-43-expressing cells, CQ fails to synergize with HQ-161 and actually antagonizes HQ-161 rescuing activity. In contrast, despite the fact that CQ was completely inactive against TDP-43, it strongly synergized with HQ-415, decreasing the EC50 from 16 to 5 μM. HQ-415 is active in the TDP-43 model, but CQ was not HQ-161 and HQ-415 are retested in dose for their ability to rescue TDP-43. Both HQ-161 and HQ-415 rescue TDP-43 toxicity. In cells expressing α-syn, HQ-161, despite being inactive on its own, synergized with HQ-415, reducing the EC50 from 21 to 14 μM. HQ-415 strongly synergizes with CQ at multiple concentrations in cells expressing α-syn. |
| Name | HQ-415 |
|---|---|
| Synonym | More Synonyms |
| Description | HQ-415 is a class of clinically relevant bioactive metal chelators related to clioquinol. The effective concentration eliciting a EC50 for HQ-415 is 15 μM. IC50 value: 15 μM (EC50)in vitro: In TDP-43-expressing cells, CQ fails to synergize with HQ-161 and actually antagonizes HQ-161 rescuing activity. In contrast, despite the fact that CQ was completely inactive against TDP-43, it strongly synergized with HQ-415, decreasing the EC50 from 16 to 5 μM. HQ-415 is active in the TDP-43 model, but CQ was not HQ-161 and HQ-415 are retested in dose for their ability to rescue TDP-43. Both HQ-161 and HQ-415 rescue TDP-43 toxicity. In cells expressing α-syn, HQ-161, despite being inactive on its own, synergized with HQ-415, reducing the EC50 from 21 to 14 μM. HQ-415 strongly synergizes with CQ at multiple concentrations in cells expressing α-syn. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 614.9±55.0 °C at 760 mmHg |
| Molecular Formula | C25H25N3O3 |
| Molecular Weight | 415.484 |
| Flash Point | 325.7±31.5 °C |
| Exact Mass | 415.189606 |
| LogP | 4.47 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.663 |
| Storage condition | 2-8℃ |
| 8-Quinolinol, 7-[(3-ethoxy-4-methoxyphenyl)[(4-methyl-2-pyridinyl)amino]methyl]- |
| 7-{(3-Ethoxy-4-methoxyphenyl)[(4-methyl-2-pyridinyl)amino]methyl}-8-quinolinol |