TRAF-STOP inhibitor 6877002 structure
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Common Name | TRAF-STOP inhibitor 6877002 | ||
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CAS Number | 433249-94-6 | Molecular Weight | 251.323 | |
Density | 1.1±0.1 g/cm3 | Boiling Point | 378.6±42.0 °C at 760 mmHg | |
Molecular Formula | C17H17NO | Melting Point | N/A | |
MSDS | USA | Flash Point | 133.5±28.0 °C | |
Symbol |
GHS09 |
Signal Word |
Use of TRAF-STOP inhibitor 6877002TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1[1]. TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques[2]. |
Name | (2E)-3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one |
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Synonym | More Synonyms |
Description | TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1[1]. TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques[2]. |
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Related Catalog | |
Target |
CD40-TRAF6 interaction; NF-κB |
References |
Density | 1.1±0.1 g/cm3 |
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Boiling Point | 378.6±42.0 °C at 760 mmHg |
Molecular Formula | C17H17NO |
Molecular Weight | 251.323 |
Flash Point | 133.5±28.0 °C |
Exact Mass | 251.131012 |
LogP | 3.83 |
Vapour Pressure | 0.0±0.9 mmHg at 25°C |
Index of Refraction | 1.619 |
Symbol |
GHS09 |
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Hazard Statements | H411 |
Precautionary Statements | P273-P391-P501 |
Hazard Codes | N |
RIDADR | UN 3077 9 / PGIII |
(2E)-3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one |
2-Propen-1-one, 3-[(2,5-dimethylphenyl)amino]-1-phenyl-, (2E)- |