TRAF-STOP inhibitor 6877002

Modify Date: 2024-01-11 12:59:51

TRAF-STOP inhibitor 6877002 Structure
TRAF-STOP inhibitor 6877002 structure
Common Name TRAF-STOP inhibitor 6877002
CAS Number 433249-94-6 Molecular Weight 251.323
Density 1.1±0.1 g/cm3 Boiling Point 378.6±42.0 °C at 760 mmHg
Molecular Formula C17H17NO Melting Point N/A
MSDS USA Flash Point 133.5±28.0 °C
Symbol GHS09
GHS09
Signal Word

 Use of TRAF-STOP inhibitor 6877002


TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1[1]. TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques[2].

 Names

Name (2E)-3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one
Synonym More Synonyms

 TRAF-STOP inhibitor 6877002 Biological Activity

Description TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1[1]. TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques[2].
Related Catalog
Target

CD40-TRAF6 interaction; NF-κB

References

[1]. Seijkens TTP, et al. Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis. J Am Coll Cardiol. 2018 Feb 6;71(5):527-542.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 378.6±42.0 °C at 760 mmHg
Molecular Formula C17H17NO
Molecular Weight 251.323
Flash Point 133.5±28.0 °C
Exact Mass 251.131012
LogP 3.83
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.619

 Safety Information

Symbol GHS09
GHS09
Hazard Statements H411
Precautionary Statements P273-P391-P501
Hazard Codes N
RIDADR UN 3077 9 / PGIII

 Synonyms

(2E)-3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one
2-Propen-1-one, 3-[(2,5-dimethylphenyl)amino]-1-phenyl-, (2E)-
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