Toddaculine
Modify Date: 2024-01-02 17:58:56
Toddaculine structure
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Common Name | Toddaculine | ||
|---|---|---|---|---|
| CAS Number | 4335-12-0 | Molecular Weight | 274.31200 | |
| Density | 1.138g/cm3 | Boiling Point | 432.8ºC at 760 mmHg | |
| Molecular Formula | C16H18O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 192.2ºC | |
Use of ToddaculineToddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity[1][2][3]. |
| Name | 5,7-dimethoxy-6-(3-methylbut-2-enyl)chromen-2-one |
|---|---|
| Synonym | More Synonyms |
| Description | Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Toddaculin (5-250 μM; 24-72 h) shows anti-proliferative activity in U-937 cells, with an IC50 of 51.38 μM[1]. Toddaculin (25-250 μM; 24-48 h) induces partial differentiation in U-937 leukemic cells[1]. |
| References |
| Density | 1.138g/cm3 |
|---|---|
| Boiling Point | 432.8ºC at 760 mmHg |
| Molecular Formula | C16H18O4 |
| Molecular Weight | 274.31200 |
| Flash Point | 192.2ºC |
| Exact Mass | 274.12100 |
| PSA | 48.67000 |
| LogP | 3.31890 |
| Index of Refraction | 1.547 |
| Storage condition | 2-8℃ |
| Precursor 9 | |
|---|---|
| DownStream 0 | |
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