Atecegatran metoxil

Modify Date: 2024-01-08 18:00:58

Atecegatran metoxil structure	Common Name	Atecegatran metoxil
	CAS Number	433937-93-0	Molecular Weight	496.89200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₃ClF₂N₄O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Atecegatran metoxil

Atecegatran metoxil is a oral anticoagulant, which inhibits thrombin factor II and is used in thromboembolic disorders. In vivo, Atecegatran metoxil is converted to AR-H067637, a selective and reversible direct thrombin inhibitor.

Name	Ph(3-Cl)(5-OCHF2)-(R)CH(OH)C(O)-(S)Aze-Pab(OMe)
Synonym	More Synonyms

Description	Atecegatran metoxil is a oral anticoagulant, which inhibits thrombin factor II and is used in thromboembolic disorders. In vivo, Atecegatran metoxil is converted to AR-H067637, a selective and reversible direct thrombin inhibitor.
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin
References	[1]. Lip GY, Rasmussen LH, Olsson SB, et al. Oral direct thrombin inhibitor AZD0837 for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation: a randomized dose-guiding, safety, and tolerability study of four doses of AZD0837 vs. vitamin K antagonists. Eur Heart J. 2009;30(23):2897-2907. [2]. Olsson SB, Rasmussen LH, Tveit A, et al. Safety and tolerability of an immediate-release formulation of theoral direct thrombin inhibitor AZD0837 in the prevention of stroke and systemic embolism in patients with atrial fibrillation. Thromb Haemost. 2010;103(3):604-612.

Description

Related Catalog

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin

References

[1]. Lip GY, Rasmussen LH, Olsson SB, et al. Oral direct thrombin inhibitor AZD0837 for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation: a randomized dose-guiding, safety, and tolerability study of four doses of AZD0837 vs. vitamin K antagonists. Eur Heart J. 2009;30(23):2897-2907.

[2]. Olsson SB, Rasmussen LH, Tveit A, et al. Safety and tolerability of an immediate-release formulation of theoral direct thrombin inhibitor AZD0837 in the prevention of stroke and systemic embolism in patients with atrial fibrillation. Thromb Haemost. 2010;103(3):604-612.

Molecular Formula	C₂₂H₂₃ClF₂N₄O₅
Molecular Weight	496.89200
Exact Mass	496.13300
PSA	126.48000
LogP	3.18790

Hazard Codes	Xi

Ph(3-Cl)(5-OCHF2)-(R)CH(OH)C(O)-Aze-Pab(OMe)

Ph(3-Cl)(5-OCHF2)-(R)CH(OH)C(O)-Aze-Pab(MeO)

AZD-0837

Atecegatran metoxil

Use of Atecegatran metoxil

Names

Atecegatran metoxil Biological Activity

Chemical & Physical Properties

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Synonyms