α-Synuclein (61-75)

Modify Date: 2024-01-11 15:56:16

α-Synuclein (61-75) structure	Common Name	α-Synuclein (61-75)
	CAS Number	440645-08-9	Molecular Weight	1430.56
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆₀H₁₀₃N₁₇O₂₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of α-Synuclein (61-75)

α-Synuclein (61-75) is the 61-75 fragment of α-Synuclein. α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve terminals. α-Synuclein is a potential biomarker for Parkinson's disease (PD)[1][2].

Name	α-Synuclein (61-75)

Description	α-Synuclein (61-75) is the 61-75 fragment of α-Synuclein. α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve terminals. α-Synuclein is a potential biomarker for Parkinson's disease (PD)[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Lewy bodies containing α-Synuclein are a neuropathological hallmark of PD, and missense mutations in α-Synuclein (A30P, E46K, H50Q, G51D, A53E, A53T), as well as α-Synuclein gene duplications and triplications, appear to cause PD. Moreover, polymorphisms in regulatory elements of the α-Synuclein gene predispose individuals to PD and are linked to an early onset of the disease. The non-Aβ-amyloid component (NAC) region of α-synuclein is relatively hydrophobic and aggregation-prone in human α-Synuclein but not in mouse α-Synuclein nor in the corresponding homologous region of human β-synuclein. Yet, β-synuclein is more homologous to α-synuclein in the N-terminal sequences (74%) than γ-synuclein (67%)[1].
References	[1]. Jacqueline Burré, et al. Cell Biology and Pathophysiology of α-Synuclein. Cold Spring Harb Perspect Med. 2018 Mar 1;8(3):a024091. [2]. Nelson Ferreira, et al. Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain. Acta Neuropathol Commun. 2021 Feb 25;9(1):31.

Molecular Formula	C₆₀H₁₀₃N₁₇O₂₃
Molecular Weight	1430.56

DC Chemicals Limited
China
Product Name: α-Synuclein (61-75)
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
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Taiwan Oyi peptide Co. Ltd
China
Product Name: α-Synuclein (61-75)
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Vinnie

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