CCT-031374
Modify Date: 2024-01-13 17:53:48
CCT-031374 structure
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Common Name | CCT-031374 | ||
|---|---|---|---|---|
| CAS Number | 442535-46-8 | Molecular Weight | 353.417 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 557.9±52.0 °C at 760 mmHg | |
| Molecular Formula | C23H19N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 291.2±30.7 °C | |
Use of CCT-031374CCT-031374 is a selective β-catenin signaling inhibitor with IC50 of 6.1 uM; prevents BIO-induced accumulation of β-catenin, does not alter β-catenin levels but blocks transcription at the β-catenin level; also shows activity against endogenous LEF-1 mRNA levels in human neurogenic embryoid bodies (hNEBs) in which Wnt signaling had been induced by BIO. |
| Name | 2-(1,2-dihydroimidazo[1,2-a]benzimidazol-4-yl)-1-(4-phenylphenyl)ethanone |
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| Synonym | More Synonyms |
| Description | CCT-031374 is a selective β-catenin signaling inhibitor with IC50 of 6.1 uM; prevents BIO-induced accumulation of β-catenin, does not alter β-catenin levels but blocks transcription at the β-catenin level; also shows activity against endogenous LEF-1 mRNA levels in human neurogenic embryoid bodies (hNEBs) in which Wnt signaling had been induced by BIO. |
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| References | References 1. Ewan K, et al. Cancer Res. 2010 Jul 15;70(14):5963-73. 2. Yang Y, et al. Neuroscience. 2013 Sep 17;248:383-91. 3. Liu B, et al. Int J Mol Med. 2015 Dec;36(6):1572-82. View Related Products by Target Beta-catenin |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 557.9±52.0 °C at 760 mmHg |
| Molecular Formula | C23H19N3O |
| Molecular Weight | 353.417 |
| Flash Point | 291.2±30.7 °C |
| Exact Mass | 353.152802 |
| LogP | 3.65 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.683 |
| 2-(1,2-dihydroimidazo[1,2-a]benzimidazol-4-yl)-1-(4-phenylphenyl)ethanone |
| Ethanone, 1-[1,1'-biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)- |
| 1-(4-Biphenylyl)-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone |
| MFCD01055171 |
| 1-Biphenyl-4-yl-2-(2,3-dihydro-1,3a,8-triaza-cyclopenta[a]inden-8-yl)-ethanone |
| 1-(biphenyl-4-yl)-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone |