1,2,4-Triazin-3-amine,5,6-diphenyl-

Modify Date: 2024-01-08 20:24:58

1,2,4-Triazin-3-amine,5,6-diphenyl- Structure
1,2,4-Triazin-3-amine,5,6-diphenyl- structure
Common Name 1,2,4-Triazin-3-amine,5,6-diphenyl-
CAS Number 4511-99-3 Molecular Weight 248.28300
Density 1.229g/cm3 Boiling Point 463.6ºC at 760mmHg
Molecular Formula C15H12N4 Melting Point 177ºC
MSDS N/A Flash Point 265.2ºC

 Names

Name 5,6-diphenyl-1,2,4-triazin-3-amine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.229g/cm3
Boiling Point 463.6ºC at 760mmHg
Melting Point 177ºC
Molecular Formula C15H12N4
Molecular Weight 248.28300
Flash Point 265.2ºC
Exact Mass 248.10600
PSA 64.69000
LogP 3.36900
Index of Refraction 1.653

 MSDS

Name: 5 6-Diphenyl-1 2 4-triazin-3-amine 97% Material Safety Data Sheet
Synonym:
CAS: 4511-99-3
Section 1 - Chemical Product MSDS Name:5 6-Diphenyl-1 2 4-triazin-3-amine 97% Material Safety Data Sheet
Synonym:

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
4511-99-3 5,6-Diphenyl-1,2,4-triazin-3-amine 97% unlisted
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
May cause respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 4511-99-3: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: cream
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 172 - 174 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C15H12N4
Molecular Weight: 248

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Acids, oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 4511-99-3: XY3177800 LD50/LC50:
Not available.
Carcinogenicity:
5,6-Diphenyl-1,2,4-triazin-3-amine - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 4511-99-3: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 4511-99-3 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 4511-99-3 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XY3177800
CHEMICAL NAME :
as-Triazine, 3-amino-3,6-diphenyl-
CAS REGISTRY NUMBER :
4511-99-3
BEILSTEIN REFERENCE NO. :
0207559
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C15-H12-N4
MOLECULAR WEIGHT :
248.31
WISWESSER LINE NOTATION :
T6NN DNJ CZ ER& FR&

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
145 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage)
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 95,123,1953
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 95,123,1953

 Safety Information

Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases 26-36/37/39
HS Code 2933699090

 Synthetic Route

~41%

1,2,4-Triazin-3-amine,5,6-diphenyl- Structure

1,2,4-Triazin-3...

CAS#:4511-99-3

Literature: Congreve, Miles; Andrews, Stephen P.; Dore, Andrew S.; Hollenstein, Kaspar; Hurrell, Edward; Langmead, Christopher J.; Mason, Jonathan S.; Ng, Irene W.; Tehan, Benjamin; Zhukov, Andrei; Weir, Malcolm; Marshall, Fiona H. Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 1898 - 1903

~72%

1,2,4-Triazin-3-amine,5,6-diphenyl- Structure

1,2,4-Triazin-3...

CAS#:4511-99-3

Literature: El-Khoshnieh, Yehia O. Phosphorus, Sulfur and Silicon and Related Elements, 1998 , vol. 139, p. 163 - 172

~%

1,2,4-Triazin-3-amine,5,6-diphenyl- Structure

1,2,4-Triazin-3...

CAS#:4511-99-3

Literature: Congreve, Miles; Andrews, Stephen P.; Dore, Andrew S.; Hollenstein, Kaspar; Hurrell, Edward; Langmead, Christopher J.; Mason, Jonathan S.; Ng, Irene W.; Tehan, Benjamin; Zhukov, Andrei; Weir, Malcolm; Marshall, Fiona H. Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 1898 - 1903

~88%

1,2,4-Triazin-3-amine,5,6-diphenyl- Structure

1,2,4-Triazin-3...

CAS#:4511-99-3

Literature: El-Khoshnieh, Yehia O. Phosphorus, Sulfur and Silicon and Related Elements, 1998 , vol. 139, p. 163 - 172

~%

1,2,4-Triazin-3-amine,5,6-diphenyl- Structure

1,2,4-Triazin-3...

CAS#:4511-99-3

Literature: HEPTARES THERAPEUTICS LIMITED; CONGREVE, Miles Stuart; ANDREWS, Stephen Philippe; MASON, Jonathan Stephen; RICHARDSON, Christine Mary; BROWN, Giles Albert Patent: WO2011/95625 A1, 2011 ; WO 2011/095625 A1

~%

1,2,4-Triazin-3-amine,5,6-diphenyl- Structure

1,2,4-Triazin-3...

CAS#:4511-99-3

Literature: HEPTARES THERAPEUTICS LIMITED; CONGREVE, Miles Stuart; ANDREWS, Stephen Philippe; MASON, Jonathan Stephen; RICHARDSON, Christine Mary; BROWN, Giles Albert Patent: WO2011/95625 A1, 2011 ; WO 2011/095625 A1

~%

1,2,4-Triazin-3-amine,5,6-diphenyl- Structure

1,2,4-Triazin-3...

CAS#:4511-99-3

Literature: El-Khoshnieh, Yehia O. Phosphorus, Sulfur and Silicon and Related Elements, 1998 , vol. 139, p. 163 - 172

~%

1,2,4-Triazin-3-amine,5,6-diphenyl- Structure

1,2,4-Triazin-3...

CAS#:4511-99-3

Literature: Thiele; Bihan Justus Liebigs Annalen der Chemie, 1898 , vol. 302, p. 307

 Customs

HS Code 2933699090
Summary 2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%

 Synonyms

1,2,4-Triazin-3-amine,5,6-diphenyl
as-Triazine,3-amino-3,6-diphenyl
3-Amino-5,6-diphenyl-as-triazine
as-Triazine,3-amino-5,6-diphenyl
5,6-diphenyl-1,2,4-triazine-3-amine
3-Amino-5,6-diphenyl-1,2,4-triazine
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