H-Glu-OtBu

Modify Date: 2024-01-02 13:36:06

H-Glu-OtBu Structure
H-Glu-OtBu structure
 Common Name H-Glu-OtBu
CAS Number 45120-30-7 Molecular Weight 203.236
Density 1.1±0.1 g/cm3 Boiling Point 326.8±32.0 °C at 760 mmHg
Molecular Formula C9H17NO4 Melting Point 140ºC
MSDS N/A Flash Point 151.5±25.1 °C

 Use of H-Glu-OtBu


H-Glu-OtBu is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Glu-OtBu is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2

 Names

Name (S)-4-Amino-5-(tert-butoxy)-5-oxopentanoic acid
Synonym More Synonyms

 H-Glu-OtBu Biological Activity

Description H-Glu-OtBu is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Glu-OtBu is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2
Related Catalog
Target

Non-cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 326.8±32.0 °C at 760 mmHg
Melting Point 140ºC
Molecular Formula C9H17NO4
Molecular Weight 203.236
Flash Point 151.5±25.1 °C
Exact Mass 203.115753
PSA 89.62000
LogP 0.77
Appearance of Characters Powder | White
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.476
Storage condition Store at 0°C

 Safety Information

Hazard Codes Xi
HS Code 2922509090

 Synthetic Route

Z-Glu-OtBu structure

Z-Glu-OtBu

CAS#:5891-45-2

~79%

H-Glu-OtBu Structure

H-Glu-OtBu

CAS#:45120-30-7

Literature: Eli Lilly and Company; COR Therapeutics Inc. Patent: US6291469 B1, 2001 ;
Fmoc-Glu-OtBu structure

Fmoc-Glu-OtBu

CAS#:84793-07-7

~%

H-Glu-OtBu Structure

H-Glu-OtBu

CAS#:45120-30-7

Literature: Gengrinovitch, Stela; Izakovich, Esther Patent: US2007/72800 A1, 2007 ; Location in patent: Page/Page column 13 ;
L-Glutamic acid, 1-(1,1-dimethylethyl) 5-(phenylmethyl) ester structure

L-Glutamic acid...

CAS#:80165-23-7

~%

H-Glu-OtBu Structure

H-Glu-OtBu

CAS#:45120-30-7

Literature: Roeske,R. Journal of Organic Chemistry, 1963 , vol. 28, p. 1251 - 1253
H-Glu(OBzl)-OH structure

H-Glu(OBzl)-OH

CAS#:1676-73-9

~%

H-Glu-OtBu Structure

H-Glu-OtBu

CAS#:45120-30-7

Literature: Roeske,R. Journal of Organic Chemistry, 1963 , vol. 28, p. 1251 - 1253
H-Glu(OtBu)-OtBu structure

H-Glu(OtBu)-OtBu

CAS#:16874-06-9

~%

L-glutamic acid structure

L-glutamic acid

CAS#:56-86-0

H-Glu(OtBu)-OH structure

H-Glu(OtBu)-OH

CAS#:2419-56-9

H-Glu-OtBu Structure

H-Glu-OtBu

CAS#:45120-30-7

Literature: Behrendt, L. Kirk Patent: US2004/30177 A1, 2004 ; Location in patent: Page 3 ;
H-Glu(OtBu)-OtBu.HCl structure

H-Glu(OtBu)-OtBu.HCl

CAS#:32677-01-3

~%

L-glutamic acid structure

L-glutamic acid

CAS#:56-86-0

H-Glu(OtBu)-OH structure

H-Glu(OtBu)-OH

CAS#:2419-56-9

H-Glu-OtBu Structure

H-Glu-OtBu

CAS#:45120-30-7

Literature: Behrendt, L. Kirk Patent: US2004/30177 A1, 2004 ; Location in patent: Page 3 ;

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

L-Glutamic acid, 1-(1,1-dimethylethyl) ester
L-Glutamic acid α-tert·butyl ester
(4S)-4-Amino-5-[(2-methyl-2-propanyl)oxy]-5-oxopentanoic acid
(4S)-4-Amino-5-tert-butoxy-5-oxopentanoic acid (non-preferred name)
H-Glu-OtBu
Top Suppliers:I want be here

Get all suppliers and price by the below link:

H-Glu-OtBu suppliers

H-Glu-OtBu price

Related Compounds: More...
H-Glu-OtBu
144313-55-3
H-Glu(OtBu)-OtBu
16874-06-9
H-Glu(OtBu)-OMe·HCl
6234-01-1
H-Glu(OtBu)-OH
2419-56-9
H-Glu(OtBu)-NH2.HCl
108607-02-9
h-glu(otbu)-leu-ome hcl
85101-25-3
H-Glu(OtBu)-OBzl.HCl
98102-32-0
H-Glu(OtBu)-OtBu.HCl
32677-01-3
Fmoc-Glu(OBut)-ODhbt
114119-86-7
2h-1-Benzopyran-6-ol,2-[[5-(2,3-dihydro-1h-indol-7-yl)-1h-pyrazol-1-yl]methyl]-3,4-dihydro-2,5,7,8-tetramethyl-
1198873-73-2
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1158522-08-7
2-[5-Fluoro-4-methoxy-2-(2,2,2-trifluoro-ethyl)-phenyl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
1421503-67-4
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
940364-43-2
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
134104-43-1
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
131615-57-1
(4-Methyl-tetrahydro-furan-2-yl)-methanol
6906-52-1
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
930439-75-1
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
1018584-77-4
N-benzyl-2-[5-(4-methoxyphenyl)-4,6-dioxo-8-thia-3,5-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),10,12-tetraen-3-yl]acetamide
902294-80-8
Chemsrc provides H-Glu-OtBu(CAS#:45120-30-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of H-Glu-OtBu are included as well.>> amp version: H-Glu-OtBu

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved