3,3'-diiodo-L-thyronine

Modify Date: 2024-01-08 15:08:49

3,3'-diiodo-L-thyronine Structure
3,3'-diiodo-L-thyronine structure
Common Name 3,3'-diiodo-L-thyronine
CAS Number 4604-41-5 Molecular Weight 525.077
Density 2.1±0.1 g/cm3 Boiling Point 520.7±50.0 °C at 760 mmHg
Molecular Formula C15H13I2NO4 Melting Point 178-180ºC
MSDS USA Flash Point 268.7±30.1 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 3,3'-diiodo-L-thyronine


3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity[1][2].

 Names

Name 3,3'-diiodo-L-thyronine
Synonym More Synonyms

 3,3'-diiodo-L-thyronine Biological Activity

Description 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity[1][2].
Related Catalog
Target

Human Endogenous Metabolite

COX

In Vitro 3,3'-Diiodo-L-thyronine (3,3'-T2; 1 μM; 30 min) significantly enhances COX activity[2]. 3,3'-Diiodo-L-thyronine of 1 μM has the maximum effect[2]. 3,3'-Diiodo-L-thyronine is produced by further degradation of T3 and rT3[3].
References

[1]. Lorenzini L, et al. Assay of Endogenous 3,5-diiodo-L-thyronine (3,5-T2) and 3,3'-diiodo-L-thyronine (3,3'-T2) in Human Serum: A Feasibility Study. Front Endocrinol (Lausanne). 2019 Feb 19;10:88.

[2]. Lanni A, et al. Rapid stimulation in vitro of rat liver cytochrome oxidase activity by 3,5-diiodo-L-thyronine and by 3,3'-diiodo-L-thyronine. Mol Cell Endocrinol. 1994 Feb;99(1):89-94.

[3]. Chen X, et al. Simultaneous quantification of T4, T3, rT3, 3,5-T2 and 3,3'-T2 in larval zebrafish (Danio rerio) as a model to study exposure to polychlorinated biphenyls. Biomed Chromatogr. 2018 Jun;32(6):e4185.

 Chemical & Physical Properties

Density 2.1±0.1 g/cm3
Boiling Point 520.7±50.0 °C at 760 mmHg
Melting Point 178-180ºC
Molecular Formula C15H13I2NO4
Molecular Weight 525.077
Flash Point 268.7±30.1 °C
Exact Mass 524.893372
PSA 92.78000
LogP 4.55
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.726
Storage condition Amber Vial, -20°C Freezer, Under Inert Atmosphere

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Hazard Codes Xi
RIDADR NONH for all modes of transport

 Articles361

More Articles
Redesigned Escherichia coli cytosine deaminase: a new facet of suicide gene therapy.

J. Gene Med. 17 , 132-9, (2015)

The Escherichia coli cytosine deaminase (CD)/5-fluorocytosine (5-FC) approach emerges as a potential aid for suicide gene therapy in the field of modern cancer treatment. However, the poor binding aff...

Axial T1ρ MRI as a diagnostic imaging modality to quantify proteoglycan concentration in degenerative disc disease.

Eur. Spine J. 24 , 2395-401, (2015)

The aim of the study was to investigate if axial T1ρ MR images had similar accuracy as established sagittal T1ρ MRI for the assessment of proteoglycan concentration and content in intervertebral degen...

Spider wrapping silk fibre architecture arising from its modular soluble protein precursor.

Sci. Rep. 5 , 11502, (2015)

Spiders store spidroins in their silk glands as high concentration aqueous solutions, spinning these dopes into fibres with outstanding mechanical properties. Aciniform (or wrapping) silk is the tough...

 Synonyms

3,3’-Diiodo-L-thyronine
O-(4-Hydroxy-3-iodophenyl)-3-iodo-L-tyrosine
3,3'-Diiodo-L-thyronine
L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3-iodo-
EINECS 225-005-7