3-O-(2'E,4'E-Decadienoyl)-ingenol

Modify Date: 2024-01-20 11:34:10

3-O-(2'E,4'E-Decadienoyl)-ingenol Structure
3-O-(2'E,4'E-Decadienoyl)-ingenol structure
Common Name 3-O-(2'E,4'E-Decadienoyl)-ingenol
CAS Number 466663-11-6 Molecular Weight 498.651
Density 1.2±0.1 g/cm3 Boiling Point 635.6±55.0 °C at 760 mmHg
Molecular Formula C30H42O6 Melting Point N/A
MSDS N/A Flash Point 201.7±25.0 °C

 Use of 3-O-(2'E,4'E-Decadienoyl)-ingenol


3-O-(2'E,4'E-Decadienoyl)-ingenol is a natural diterpenoid that shows cytotoxicity against human normal cell lines L-O2 and GES-1, with IC50s of 8.22 μM and 6.67 μM, respectively[1].

 Names

Name 3-O-(2'E,4'E-Decadienoyl)ingenol
Synonym More Synonyms

 3-O-(2'E,4'E-Decadienoyl)-ingenol Biological Activity

Description 3-O-(2'E,4'E-Decadienoyl)-ingenol is a natural diterpenoid that shows cytotoxicity against human normal cell lines L-O2 and GES-1, with IC50s of 8.22 μM and 6.67 μM, respectively[1].
Related Catalog
In Vitro 3-O-(2'E,4'E-Decadienoyl)-ingenol(5-30 μg/mL;24 小时)显示出对人类正常细胞系 L-O2 和 GES-1 的细胞毒性,具有剂量依赖关系 [1]。 Cell Cytotoxicity Assay[1] Cell Line: L-O2 and GES-1 cells Concentration: 5 μg/mL, 10 μg/mL,15 μg/mL, 20 μg/mL, 25 μg/mL, 30 μg/mL Incubation Time: 24 hours Result: Showed cytotoxicity against human normal cell lines L-O2 and GES-1 with dose-dependent relationships.
References

[1]. Li Zhang, et al. Bio-guided isolation of the cytotoxic terpenoids from the roots of Euphorbia kansui against human normal cell lines L-O2 and GES-1. Int J Mol Sci. 2012;13(9):11247-11259.  

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 635.6±55.0 °C at 760 mmHg
Molecular Formula C30H42O6
Molecular Weight 498.651
Flash Point 201.7±25.0 °C
Exact Mass 498.298126
LogP 7.30
Vapour Pressure 0.0±4.2 mmHg at 25°C
Index of Refraction 1.584

 Synonyms

2,4-Decadienoic acid, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester, (2E,4E)-
(1S,4S,5S,6R,9S,10R,12R,14R)-5,6-Dihydroxy-7-(hydroxymethyl)-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.01,5.010,12]pentadeca-2,7-dien-4-yl (2E,4E)-2,4-decadienoate
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