N-Desmethylnefopam

Modify Date: 2024-01-02 20:59:33

N-Desmethylnefopam Structure
N-Desmethylnefopam structure
 Common Name N-Desmethylnefopam
CAS Number 46868-19-3 Molecular Weight 239.31200
Density 1.073g/cm3 Boiling Point 383.4ºC at 760 mmHg
Molecular Formula C16H17NO Melting Point N/A
MSDS N/A Flash Point 157.1ºC

 Use of N-Desmethylnefopam


N-Desmethylnefopam is the main metabolite of Nefopam. N-Desmethylnefopam is a centrally-acting but non-opioid analgesic agent, for the relief of moderate to severe pain. Nefopam targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo[1][2][3].

 Names

Name 1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine
Synonym More Synonyms

 N-Desmethylnefopam Biological Activity

Description N-Desmethylnefopam is the main metabolite of Nefopam. N-Desmethylnefopam is a centrally-acting but non-opioid analgesic agent, for the relief of moderate to severe pain. Nefopam targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo[1][2][3].
Related Catalog
References

[1]. Mittur A. A Simultaneous Mixed-Effects Pharmacokinetic Model for Nefopam, N-desmethylnefopam, and Nefopam N-Oxide in Human Plasma and Urine. Eur J Drug Metab Pharmacokinet. 2018 Aug;43(4):391-404.

[2]. Kim KH, et al. Rediscovery of nefopam for the treatment of neuropathic pain. Korean J Pain. 2014 Apr;27(2):103-11.

[3]. Baht GS, et al. Pharmacologically targeting beta-catenin for NF1 associated deficiencies in fracture repair. Bone. 2017 May;98:31-36.

 Chemical & Physical Properties

Density 1.073g/cm3
Boiling Point 383.4ºC at 760 mmHg
Molecular Formula C16H17NO
Molecular Weight 239.31200
Flash Point 157.1ºC
Exact Mass 239.13100
PSA 21.26000
LogP 3.22460
Index of Refraction 1.563

 Synthetic Route

1-phenyl-1,3,4,6-tetrahydro-1H-2,5-benzoxazocine-5-propanenitrile structure

1-phenyl-1,3,4,...

CAS#:47205-41-4

~85%

N-Desmethylnefopam Structure

N-Desmethylnefopam

CAS#:46868-19-3
Literature: Rosamilia, Anthony E.; Mayes, Penelope A.; Papadopoulos, Roslyn; Campi, Eva M.; Jackson, W. Roy; Rash, Lachlan; Jarrott, Bevyn Australian Journal of Chemistry, 2002 , vol. 55, # 9 p. 577 - 585
1-PHENYL-3,4,5,6-TETRAHYDRO-1H-2,5-BENZOXAZOCINE-5-CARBONITRILE structure

1-PHENYL-3,4,5,...

CAS#:84940-28-3

~10%

N-Desmethylnefopam Structure

N-Desmethylnefopam

CAS#:46868-19-3
Literature: Rosamilia, Anthony E.; Mayes, Penelope A.; Papadopoulos, Roslyn; Campi, Eva M.; Jackson, W. Roy; Rash, Lachlan; Jarrott, Bevyn Australian Journal of Chemistry, 2002 , vol. 55, # 9 p. 577 - 585
2-(2'-hydroxyethyl)amino-5-phenyl-2,5-dihydro-3,4-benzofuran structure

2-(2'-hydroxyet...

CAS#:147678-38-4

~%

N-Desmethylnefopam Structure

N-Desmethylnefopam

CAS#:46868-19-3
Literature: Glaser; Geresh; Blumenfeld; Donnell; Sugisaka; Drouin; Michel Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 3 p. 276 - 281
3-phenyl-1,3-dihydro-2-benzofuran-1-ol structure

3-phenyl-1,3-di...

CAS#:65184-67-0

~%

N-Desmethylnefopam Structure

N-Desmethylnefopam

CAS#:46868-19-3
Literature: Glaser; Geresh; Blumenfeld; Donnell; Sugisaka; Drouin; Michel Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 3 p. 276 - 281
o-Phthalaldehyde structure

o-Phthalaldehyde

CAS#:643-79-8

~%

N-Desmethylnefopam Structure

N-Desmethylnefopam

CAS#:46868-19-3
Literature: Glaser; Geresh; Blumenfeld; Donnell; Sugisaka; Drouin; Michel Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 3 p. 276 - 281
2-(2'-hydroxyethyl)aminomethylbenzhydrol structure

2-(2'-hydroxyet...

CAS#:13678-15-4

~%

N-Desmethylnefopam Structure

N-Desmethylnefopam

CAS#:46868-19-3
Literature: Glaser; Geresh; Blumenfeld; Donnell; Sugisaka; Drouin; Michel Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 3 p. 276 - 281
2-Benzoylbenzoic acid structure

2-Benzoylbenzoi...

CAS#:85-52-9

~%

N-Desmethylnefopam Structure

N-Desmethylnefopam

CAS#:46868-19-3
Literature: Rosamilia, Anthony E.; Mayes, Penelope A.; Papadopoulos, Roslyn; Campi, Eva M.; Jackson, W. Roy; Rash, Lachlan; Jarrott, Bevyn Australian Journal of Chemistry, 2002 , vol. 55, # 9 p. 577 - 585
2-(1-PHENYL-2,3-DIHYDRO-1H-ISOINDOL-2-YL)ETHANOL structure

2-(1-PHENYL-2,3...

CAS#:18409-76-2

~%

N-Desmethylnefopam Structure

N-Desmethylnefopam

CAS#:46868-19-3
Literature: Rosamilia, Anthony E.; Mayes, Penelope A.; Papadopoulos, Roslyn; Campi, Eva M.; Jackson, W. Roy; Rash, Lachlan; Jarrott, Bevyn Australian Journal of Chemistry, 2002 , vol. 55, # 9 p. 577 - 585

 Synonyms

desmethyl nefopam
nor-nefopam
1H-2,5-Benzoxazocine,3,4,5,6-tetrahydro-1-phenyl
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