zerumbone

Modify Date: 2024-01-04 18:14:41

zerumbone structure	Common Name	zerumbone
	CAS Number	471-05-6	Molecular Weight	218.335
	Density	0.9±0.1 g/cm3	Boiling Point	321.6±42.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₂₂O	Melting Point	67-69℃
	MSDS	Chinese USA	Flash Point	133.9±22.8 °C
	Symbol	GHS07, GHS09	Signal Word	Warning

Use of zerumbone

Zerumbone is a monocyclic sesquiterpene compound isolated from the rhizomes of Zingiber zerumbet Smith. Zerumbone potently inhibits the activation of Epstein-Barr virus with an IC50 of 0.14 mM. Zerumbone has anti-cancer, antioxidant, anti-inflammatory and anti-proliferative activity[1][2].

Name	zerumbone
Synonym	More Synonyms

Description	Zerumbone is a monocyclic sesquiterpene compound isolated from the rhizomes of Zingiber zerumbet Smith. Zerumbone potently inhibits the activation of Epstein-Barr virus with an IC50 of 0.14 mM. Zerumbone has anti-cancer, antioxidant, anti-inflammatory and anti-proliferative activity[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection
References	[1]. Murakami A, et al. Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation. Biosci Biotechnol Biochem. 1999 Oct;63(10):1811-2. [2]. Kalantari K, et al. A Review of the Biomedical Applications of Zerumbone and the Techniques for Its Extractionfrom Ginger Rhizomes. Molecules. 2017 Sep 30;22(10).

Description

Related Catalog

Signaling Pathways >> Anti-infection >> HSV

Research Areas >> Infection

References

[1]. Murakami A, et al. Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation. Biosci Biotechnol Biochem. 1999 Oct;63(10):1811-2.

[2]. Kalantari K, et al. A Review of the Biomedical Applications of Zerumbone and the Techniques for Its Extractionfrom Ginger Rhizomes. Molecules. 2017 Sep 30;22(10).

Density	0.9±0.1 g/cm3
Boiling Point	321.6±42.0 °C at 760 mmHg
Melting Point	67-69℃
Molecular Formula	C₁₅H₂₂O
Molecular Weight	218.335
Flash Point	133.9±22.8 °C
Exact Mass	218.167068
PSA	17.07000
LogP	5.34
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.468
Storage condition	2-8℃

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H317-H400
Precautionary Statements	P273-P280
Hazard Codes	Xn
Risk Phrases	43-50
Safety Phrases	36/37-60-61
RIDADR	UN 3077 9 / PGIII

Zingiber zerumbet CYP71BA1 catalyzes the conversion of α-humulene to 8-hydroxy-α-humulene in zerumbone biosynthesis.

Cell. Mol. Life Sci. 68(6) , 1033-40, (2011)

Plant cytochrome P450s are involved in the biosynthesis of various classes of secondary metabolites. To elucidate the biosynthesis of zerumbone, a sesquiterpenoid with multiple potential anticancer pr...

Altered cross-linking of HSP27 by zerumbone as a novel strategy for overcoming HSP27-mediated radioresistance.

Int. J. Radiat. Oncol. Biol. Phys. 79(4) , 1196-205, (2011)

HSP27 or HSP25 negatively regulates apoptosis pathways after radiation or chemotherapeutic agents. Abrogation of HSP27 function may be a candidate target for overcoming radio- and chemoresistance.Zeru...

Effects of selected food phytochemicals in reducing the toxic actions of TCDD and p,p'-DDT in U937 macrophages.

Arch. Toxicol. 84(12) , 957-66, (2010)

To assess the effectiveness of selected food phytochemicals in reducing the toxic effects of the environmental toxicants, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and p,p'-DDT (DDT), we tested the p...

(2E,6E,10E)-2,6,9,9-Tetramethyl-2,6,10-cycloundecatrien-1-one

(2E,6E,10E)-2,6,9,9-Tetramethylcycloundeca-2,6,10-trien-1-one

2,6,10-Cycloundecatrien-1-one, 2,6,9,9-tetramethyl-, (2E,6E,10E)-

ZERUMBONE ((2E,6E,10E)-2,6,9,9-TETRAMETHYLCYCLOUNDECA-2,6,10-TRIEN-1-ONE)

zerumbone