Ruscogenin

Modify Date: 2024-01-02 18:04:25

Ruscogenin Structure
Ruscogenin structure
 Common Name Ruscogenin
CAS Number 472-11-7 Molecular Weight 430.62
Density 1.2±0.1 g/cm3 Boiling Point 563.1±50.0 °C at 760 mmHg
Molecular Formula C27H42O4 Melting Point 198-202ºC
MSDS Chinese USA Flash Point 294.4±30.1 °C

 Use of Ruscogenin


Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway and exerts significant anti-inflammatory and anti-thrombotic activities[1][2].

 Names

Name Ruscogenin
Synonym More Synonyms

 Ruscogenin Biological Activity

Description Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway and exerts significant anti-inflammatory and anti-thrombotic activities[1][2].
Related Catalog
References

[1]. Cao G, et al. Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway. Int J Mol Sci. 2016 Aug 29;17(9). pii: E1418.

[2]. Huang YL, et al. Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB. J Pharmacol Sci. 2008 Oct;108(2):198-205.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 563.1±50.0 °C at 760 mmHg
Melting Point 198-202ºC
Molecular Formula C27H42O4
Molecular Weight 430.62
Flash Point 294.4±30.1 °C
Exact Mass 430.308319
PSA 58.92000
LogP 4.29
Vapour Pressure 0.0±3.5 mmHg at 25°C
Index of Refraction 1.577
Storage condition 2~8℃

 Safety Information

Hazard Codes Xi
Safety Phrases 24/25
RIDADR NONH for all modes of transport
HS Code 29389090

 Synthetic Route

 Synonyms

(1β,3β,25R)-Spirost-5-ene-1,3-diol
25D-Spirost-5-ene-1|A,3|A-diol
(25R)-Spirost-5-ene-1b,3b-diol
(25R)-Spirost-5-ene-1β,3β-diol
(1β,3β,25R)-Spirost-5-en-1,3-diol
Spirost-5-en-1,3-diol, (1β,3β,25R)-
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Chemsrc provides Ruscogenin(CAS#:472-11-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Ruscogenin are included as well.>> amp version: Ruscogenin

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