(S)-Bromoenol lactone

Modify Date: 2024-01-12 18:21:46

(S)-Bromoenol lactone Structure
(S)-Bromoenol lactone structure
Common Name (S)-Bromoenol lactone
CAS Number 478288-94-7 Molecular Weight 317.177
Density 1.5±0.1 g/cm3 Boiling Point 467.0±45.0 °C at 760 mmHg
Molecular Formula C16H13BrO2 Melting Point N/A
MSDS N/A Flash Point 236.2±28.7 °C

 Use of (S)-Bromoenol lactone


(S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase A2β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 of 2 µM[1].

 Names

Name (S)-Bromoenol lactone
Synonym More Synonyms

 (S)-Bromoenol lactone Biological Activity

Description (S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase A2β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 of 2 µM[1].
Related Catalog
Target

PLA2

References

[1]. Jenkins CM, et al. Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s. J Biol Chem. 2002 Sep 6;277(36):32807-14.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 467.0±45.0 °C at 760 mmHg
Molecular Formula C16H13BrO2
Molecular Weight 317.177
Flash Point 236.2±28.7 °C
Exact Mass 316.009888
PSA 26.30000
LogP 4.36
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.716

 Synonyms

2H-Pyran-2-one, 6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-, (3S,6E)-
(3S,6E)-6-(Bromomethylene)-3-(1-naphthyl)tetrahydro-2H-pyran-2-one
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