NBQX disodium salt

Modify Date: 2024-01-09 15:57:35

NBQX disodium salt structure	Common Name	NBQX disodium salt
	CAS Number	479347-86-9	Molecular Weight	380.244
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₆N₄Na₂O₆S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of NBQX disodium salt

NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity[1].

Name	disodium,6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-diolate
Synonym	More Synonyms

Description	NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	AMPA receptor[1]
In Vitro	NBQX disodium (FG9202 disodium) has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex[1].
In Vivo	NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) decreases seizures induced by PTZ[2]. NBQX disodium is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion[1]. Animal Model: Male Wistar rats that weighed 220-240 g with pentylenetetrazole (PTZ)[2] Dosage: 20 mg/kg Administration: IP; for 3 days Result: Effectively reversed the behavioral abnormality of epileptic seizures of chronic PTZ administration (50mg/kg; i.p.; for 28 days) in rats.
References	[1]. Fukushima K, et al. Characterization of Human Hippocampal Neural Stem/Progenitor Cells and Their Application to Physiologically Relevant Assays for Multiple Ionotropic Glutamate Receptors. J Biomol Screen. 2014 Sep; 19(8):1174-84. [2]. Wen Chen, et al. AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets. PLoS One. 2016 Nov 23;11(11):e0166672.

Molecular Formula	C₁₂H₆N₄Na₂O₆S
Molecular Weight	380.244
Exact Mass	379.980347
PSA	186.26000
LogP	3.93050

Disodium 6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-diolate

Benzo[f]quinoxaline-7-sulfonamide, 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-, sodium salt (1:2)

FG9202 disodium

NBQX disodium

FG 9202 disodium salt hydrate

NBQX,Disodium Salt

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: NBQX disodium salt
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: NBQX disodium
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: NBQX disodium
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

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