Pinocembrin

Modify Date: 2024-01-02 13:40:11

Pinocembrin structure	Common Name	Pinocembrin
	CAS Number	480-39-7	Molecular Weight	256.25
	Density	1.4±0.1 g/cm3	Boiling Point	511.1±50.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₂O₄	Melting Point	N/A
	MSDS	USA	Flash Point	199.3±23.6 °C

Use of Pinocembrin

Pinocembrin ((+)-Pinocoembrin) is a flavonoid found in propolis, acts as a competitive inhibitor of histidine decarboxylase, and is an effective anti-allergic agent, with antioxidant, antimicrobial and anti-inflammatory properties[1].

Name	pinocembrin
Synonym	More Synonyms

Description	Pinocembrin ((+)-Pinocoembrin) is a flavonoid found in propolis, acts as a competitive inhibitor of histidine decarboxylase, and is an effective anti-allergic agent, with antioxidant, antimicrobial and anti-inflammatory properties[1].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Pinocembrin (5, 10, 25, 50, 100 or 200 µM, 24 hours) significantly reduces cell viability of RBL-2H3 cells[1]. Pinocembrin (25 or 50 µM) suppresses iNOS, PGE-2 and COX-2 levels, increases p38-Mapk and IкB-α, and inhibits phosphorylation of IкB-α[1]. Cell Viability Assay[1] Cell Line: RBL-2H3 cells Concentration: 5, 10, 25, 50, 100 or 200 µM Incubation Time: 24 hours Result: Decreased cell viability by ∼50% at ≥ 100 µM. Showed 75% cell viability at lower concentrations.
References	[1]. Hanieh H, et al. Pinocembrin, a novel histidine decarboxylase inhibitor with anti-allergic potential in in vitro. Eur J Pharmacol. 2017 Nov 5;814:178-186.

Density	1.4±0.1 g/cm3
Boiling Point	511.1±50.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₂O₄
Molecular Weight	256.25
Flash Point	199.3±23.6 °C
Exact Mass	256.073547
PSA	66.76000
LogP	3.93
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.662

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NQ5233332

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (S)-

CAS REGISTRY NUMBER :: 480-39-7

LAST UPDATED :: 199806

DATA ITEMS CITED :: 1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DARUEE Dokl Akad Nauk resp. Uzb. Volume(issue)/page/year: (9-10),55,1995

Safety Phrases	24/25

Precursor 3
CAS#:480-40-0 Chrysin CAS#:100-52-7 Benzaldehyde CAS#:6157-13-7 1-[2-hydroxy-4,...
DownStream 4
CAS#:109592-60-1 pinocembrin 7-a... CAS#:480-40-0 Chrysin CAS#:75291-74-6 Pinostrobin CAS#:19309-14-9 Cardamonin