3,4,5-trihydroxy-6-methylphthalaldehyde

Modify Date: 2024-01-10 12:03:50

3,4,5-trihydroxy-6-methylphthalaldehyde Structure
3,4,5-trihydroxy-6-methylphthalaldehyde structure
Common Name 3,4,5-trihydroxy-6-methylphthalaldehyde
CAS Number 483-53-4 Molecular Weight 196.15700
Density 1.577g/cm3 Boiling Point 353.7ºC at 760mmHg
Molecular Formula C9H8O5 Melting Point N/A
MSDS N/A Flash Point 181.9ºC

 Use of 3,4,5-trihydroxy-6-methylphthalaldehyde


Flavipin is an aryl hydrocarbon receptor (Ahr) agonist that induces the expression of Ahr downstream genes in mouse CD4+ T cells and CD11b+ macrophages. Flavipin inhibits the stabilizing function of Arid5a on Il23a 3′UTR, a newly identified target mRNA[1]. Flavipin exhibits the DPPH free radical scavenging ability with IC50 value of 7.2 μM, and has potent α-glucosidase inhibition with IC50 value of 33.8 μM[2].

 Names

Name 3,4,5-trihydroxy-6-methylphthalaldehyde
Synonym More Synonyms

 3,4,5-trihydroxy-6-methylphthalaldehyde Biological Activity

Description Flavipin is an aryl hydrocarbon receptor (Ahr) agonist that induces the expression of Ahr downstream genes in mouse CD4+ T cells and CD11b+ macrophages. Flavipin inhibits the stabilizing function of Arid5a on Il23a 3′UTR, a newly identified target mRNA[1]. Flavipin exhibits the DPPH free radical scavenging ability with IC50 value of 7.2 μM, and has potent α-glucosidase inhibition with IC50 value of 33.8 μM[2].
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References

[1]. "Alzahrani A, et al. Differential modulation of Ahr and Arid5a: A promising therapeutic strategy for autoimmune encephalomyelitis. Saudi Pharm J. 2020;28(12):1605-1615. "

[2]. Li H, et al. Polyketides from two Chaetomium species and their biological functions. J Antibiot (Tokyo). 2018;71(7):677-681.

 Chemical & Physical Properties

Density 1.577g/cm3
Boiling Point 353.7ºC at 760mmHg
Molecular Formula C9H8O5
Molecular Weight 196.15700
Flash Point 181.9ºC
Exact Mass 196.03700
PSA 94.83000
LogP 0.73680
Vapour Pressure 1.73E-05mmHg at 25°C
Index of Refraction 1.741

 Synonyms

1,2-Benzenedicarboxaldehyde,3,4,5-trihydroxy-6-methyl
3,4,5-Trihydroxy-6-methyl-1,2-benzenedicarboxaldehyde
Phthalaldehyde,3,4,5-trihydroxy-6-methyl
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