Toddalolactone

Modify Date: 2024-01-02 10:10:31

Toddalolactone Structure
Toddalolactone structure
 Common Name Toddalolactone
CAS Number 483-90-9 Molecular Weight 308.326
Density 1.3±0.1 g/cm3 Boiling Point 530.0±50.0 °C at 760 mmHg
Molecular Formula C16H20O6 Melting Point N/A
MSDS N/A Flash Point 195.5±23.6 °C

 Use of Toddalolactone


Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC50 value of 37.31 μM[1].

 Names

Name 6-[(2R)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxychromen-2-one
Synonym More Synonyms

 Toddalolactone Biological Activity

Description Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC50 value of 37.31 μM[1].
Related Catalog
In Vitro Toddalolactone, a natural coumarin, inhibits PAI-1 activity by preventing the formation of a stable PAI-1/uPA covalent complex, suggesting that the inhibitory effect of Toddalolactone may be due to the interference of close contact between plasminogen activator and the active center of PAI-1[1].
References

[1]. Yu B, et al. Inhibition of PAI-1 Activity by Toddalolactone as a Mechanism for Promoting Blood Circulation and Removing Stasis by Chinese Herb Zanthoxylum nitidum var. tomentosum. Front Pharmacol. 2017 Jul 21;8:489.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 530.0±50.0 °C at 760 mmHg
Molecular Formula C16H20O6
Molecular Weight 308.326
Flash Point 195.5±23.6 °C
Exact Mass 308.125977
PSA 89.13000
LogP 0.88
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.569
Storage condition 2-8C

 Synthetic Route

2H-​1-​Benzopyran-​2-​one, 6-​[(2R)​-​2-​hydroxy-​3-​methyl-​3-​buten-​1-​yl]​-​5,​7-​dimethoxy structure

2H-​1-​Benzopyr...

CAS#:137764-14-8

~15%

Toddanone structure

Toddanone

CAS#:77636-08-9

Toddalolactone Structure

Toddalolactone

CAS#:483-90-9

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 13 p. 1681 - 1684

 Precursor & DownStream

Precursor  1

DownStream  0

 Synonyms

2H-1-Benzopyran-2-one, 6-(2,3-dihydroxy-3-methylbutyl)-5,7-dimethoxy-
6-[(2r)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxy-2h-chromen-2-one
6-(2,3-Dihydroxy-3-methylbutyl)-5,7-dimethoxy-2H-chromen-2-one
(+)-toddalolactone
Toddaline
Toddalolactone
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Chemsrc provides Toddalolactone(CAS#:483-90-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Toddalolactone are included as well.>> amp version: Toddalolactone

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