Osthenol

Modify Date: 2024-01-06 18:07:00

Osthenol structure	Common Name	Osthenol
	CAS Number	484-14-0	Molecular Weight	230.25900
	Density	1.203g/cm3	Boiling Point	422.8ºC at 760 mmHg
	Molecular Formula	C₁₄H₁₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	184.1ºC

Use of Osthenol

Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM). Osthenol potently inhibits recombinant hMAO-A with an IC50 of 0.74 µM and shows a high selectivity index for hMAO-A versus hMAO-B[1].

Name	7-hydroxy-8-(3-methylbut-2-enyl)chromen-2-one
Synonym	More Synonyms

Description	Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM). Osthenol potently inhibits recombinant hMAO-A with an IC50 of 0.74 µM and shows a high selectivity index for hMAO-A versus hMAO-B[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
Target	hMAO-A:0.26 μM (Ki) hMAO-A:0.74 μM (IC50)
References	[1]. Baek SC, et al. Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity. Bioorg Med Chem Lett. 2019;29(6):839-843. [2]. Liao ZC, et al. Zhongguo Zhong Yao Za Zhi. 2017;42(15):2999-3003.

Density	1.203g/cm3
Boiling Point	422.8ºC at 760 mmHg
Molecular Formula	C₁₄H₁₄O₃
Molecular Weight	230.25900
Flash Point	184.1ºC
Exact Mass	230.09400
PSA	50.44000
LogP	3.00730
Vapour Pressure	9.53E-08mmHg at 25°C
Index of Refraction	1.595
Storage condition	2-8℃

Precursor 9
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DownStream 3
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