DPH

Modify Date: 2024-01-05 16:55:46

DPH Structure
DPH structure
Common Name DPH
CAS Number 484049-04-9 Molecular Weight 336.32000
Density N/A Boiling Point N/A
Molecular Formula C18H13FN4O2 Melting Point N/A
MSDS USA Flash Point N/A

 Use of DPH


DPH is a potent cell permeable c-Abl activator, which displays potent enzymatic and cellular activity in stimulating c-Abl activation.  

 Names

Name 5-[3-(4-fluorophenyl)-1-phenylpyrazol-4-yl]imidazolidine-2,4-dione
Synonym More Synonyms

 DPH Biological Activity

Description DPH is a potent cell permeable c-Abl activator, which displays potent enzymatic and cellular activity in stimulating c-Abl activation.  
Related Catalog
In Vitro DPH binds to the myristoyl binding site and prevents the formation of the bent conformation of the αI helix through steric hindrance, a mode of action distinct from the previously identified allosteric c-Abl inhibitor, GNF-2, that also binds to the myristoyl binding site. DPH represents the first cell-permeable, small-molecule tool compound for c-Abl activation[1].
References

[1]. Yang J, et al. Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site. Chem Biol. 2011 Feb 25;18(2):177-86

[2]. Shapiro LP, et al. Corticosteroid-induced dendrite loss and behavioral deficiencies can be blocked by activation of Abl2/Arg kinase. Mol Cell Neurosci. 2017 Oct 26;85:226-234.

 Chemical & Physical Properties

Molecular Formula C18H13FN4O2
Molecular Weight 336.32000
Exact Mass 336.10200
PSA 83.00000
LogP 2.47480
Storage condition 2-8℃

 Safety Information

RIDADR NONH for all modes of transport

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 Synonyms

5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]imidazolidine-2,4-dione
HMS2301N21
5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-2,4-imidazolidinedione
DPH
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