VU 0650991

Modify Date: 2024-01-12 22:02:01

VU 0650991 Structure
VU 0650991 structure
Common Name VU 0650991
CAS Number 488097-06-9 Molecular Weight 440.73
Density N/A Boiling Point N/A
Molecular Formula C16H11ClF6N4O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of VU 0650991


GLP-1R Antagonist 1 (compound 5d) is an orally active, CNS penetrant and non-competitive antagonist of glucagon-like peptide 1 receptor (GLP-1R), with an IC50 of 650 nM[1].

 Names

Name GLP-1R Antagonist 1

 VU 0650991 Biological Activity

Description GLP-1R Antagonist 1 (compound 5d) is an orally active, CNS penetrant and non-competitive antagonist of glucagon-like peptide 1 receptor (GLP-1R), with an IC50 of 650 nM[1].
Related Catalog
Target

IC50: 650 nM (GLP-1R)[1].

References

[1]. Kellie D. Nance, et al. Discovery of a novel series of orally bioavailable and CNS penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) non-competitive antagonists based on a 1,3-disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione core. J. Med. Chem. 19 Jan 2017.

 Chemical & Physical Properties

Molecular Formula C16H11ClF6N4O2
Molecular Weight 440.73