HOMOQUINOLINIC ACID

Modify Date: 2024-01-02 09:39:31

HOMOQUINOLINIC ACID Structure
HOMOQUINOLINIC ACID structure
Common Name HOMOQUINOLINIC ACID
CAS Number 490-75-5 Molecular Weight 181.15
Density 1.477g/cm3 Boiling Point 437ºC at 760mmHg
Molecular Formula C8H7NO4 Melting Point N/A
MSDS N/A Flash Point 218.1ºC

 Use of HOMOQUINOLINIC ACID


Homoquinolinic acid is a non endogenous agonist of NMDAR2 receptor[1][2].

 Names

Name 3-(carboxymethyl)pyridine-2-carboxylic acid
Synonym More Synonyms

 HOMOQUINOLINIC ACID Biological Activity

Description Homoquinolinic acid is a non endogenous agonist of NMDAR2 receptor[1][2].
Related Catalog
In Vitro Homoquinolinic acid (HQA,20 μM) 导致在第V层记录的事件频率显著增加[2]。 Homoquinolinic acid (HQA) 作用于突触前端,增强谷氨酸的释放[2]。
References

[1]. L P de Carvalho, et al. The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits. Neurochem Int. 1996 Apr;28(4):445-52.  

[2]. G Woodhall, et al. NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons. J Neurophysiol. 2001 Oct;86(4):1644-51.  

 Chemical & Physical Properties

Density 1.477g/cm3
Boiling Point 437ºC at 760mmHg
Molecular Formula C8H7NO4
Molecular Weight 181.15
Flash Point 218.1ºC
Exact Mass 181.03800
PSA 87.49000
LogP 0.40690
Vapour Pressure 2.07E-08mmHg at 25°C
Index of Refraction 1.607

 Synthetic Route

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HOMOQUINOLINIC ACID Structure

HOMOQUINOLINIC ACID

CAS#:490-75-5

Literature: Miescher; Kaegi Helvetica Chimica Acta, 1941 , vol. 24, p. 1471,1479

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HOMOQUINOLINIC ACID Structure

HOMOQUINOLINIC ACID

CAS#:490-75-5

Literature: Miescher; Kaegi Helvetica Chimica Acta, 1941 , vol. 24, p. 1471,1479

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HOMOQUINOLINIC ACID Structure

HOMOQUINOLINIC ACID

CAS#:490-75-5

Literature: Miescher; Kaegi Helvetica Chimica Acta, 1941 , vol. 24, p. 1471,1479

 Synonyms

Homoquinolinate
Bromocriptine mesylate
Homoquinolinic acid
Tocris-0197
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