5-Bromo-4-hydroxy-3-biphenylcarboxylic acid

Modify Date: 2024-01-10 17:01:10

5-Bromo-4-hydroxy-3-biphenylcarboxylic acid structure	Common Name	5-Bromo-4-hydroxy-3-biphenylcarboxylic acid
	CAS Number	4906-68-7	Molecular Weight	293.113
	Density	1.6±0.0 g/cm3	Boiling Point	439.2±0.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₉BrO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	219.4±0.0 °C

Use of 5-Bromo-4-hydroxy-3-biphenylcarboxylic acid

AKR1C1-IN-1 is a potent and selective inhibitor of human 20α-hydroxysteroid dehydrogenase (AKR1C1), with a Ki value of 4 nM for AKR1C1[1].

Name	3-bromo-2-hydroxy-5-phenylbenzoic acid
Synonym	More Synonyms

Description	AKR1C1-IN-1 is a potent and selective inhibitor of human 20α-hydroxysteroid dehydrogenase (AKR1C1), with a Ki value of 4 nM for AKR1C1[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	Ki: 4 nM (AKR1C1), 87 nM (AKR1C2), 4.2 μM (AKR1C3), 18.2 μM (AKR1C4)[1]
In Vitro	AKR1C1-IN-1 potently inhibits the metabolism of progesterone in AKR1C1-overexpressed BAECs, and with an IC50 of 460 nM[1].
References	[1]. El-Kabbani O, et al. Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1). J Med Chem. 2009 May 28;52(10):3259-64.

Density	1.6±0.0 g/cm3
Boiling Point	439.2±0.0 °C at 760 mmHg
Molecular Formula	C₁₃H₉BrO₃
Molecular Weight	293.113
Flash Point	219.4±0.0 °C
Exact Mass	291.974000
PSA	57.53000
LogP	4.43
Vapour Pressure	0.0±0.0 mmHg at 25°C
Index of Refraction	1.663

[1,1-Biphenyl]-3-carboxylic acid, 4-hydroxy- structure

[1,1-Biphenyl]-...

CAS#:323-87-5

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5-Bromo-4-hydroxy-3-biphenylcarboxylic acid Structure

5-Bromo-4-hydro...

CAS#:4906-68-7

Literature: Dow Chem. Co. Patent: US2779785 , 1952 ;

Precursor 1
CAS#:323-87-5 [1,1-Biphenyl]-...
DownStream 0

5-Brom-4-hydroxy-biphenyl-3-carbonsaeure

5-bromo-4-hydroxy-biphenyl-3-carboxylic acid

[1,1'-Biphenyl]-3-carboxylic acid, 3'-bromo-4-hydroxy-

3-bromo-5-phenylsalicylic acid

3-Bromo-5-phenylsalicylc acid

5-Bromo-4-hydroxy-3-biphenylcarboxylic acid

3'-Bromo-4-hydroxy-3-biphenylcarboxylic acid

[1,1'-biphenyl]-3-carboxylic acid,5-bromo-4-hydroxy

[1,1'-Biphenyl]-3-carboxylic acid, 5-bromo-4-hydroxy-

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 5-Bromo-4-hydroxy-3-biphenylcarboxylic acid
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: AKR1C1-IN-1
Price: $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: AKR1C1-IN-1
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: [1,1'-Biphenyl]-3-carboxylicacid, 5-bromo-4-hydroxy-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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