ZLN005

Modify Date: 2024-01-01 22:40:23

ZLN005 Structure
ZLN005 structure
 Common Name ZLN005
CAS Number 49671-76-3 Molecular Weight 250.338
Density 1.1±0.1 g/cm3 Boiling Point 415.3±38.0 °C at 760 mmHg
Molecular Formula C17H18N2 Melting Point 257-258℃
MSDS Chinese USA Flash Point 205.4±13.2 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of ZLN005


ZLN005 is a novel transcriptional regulator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α).IC50 value:Target: PGC-1αin vitro: ZLN005 increases expression of the PGC-1α gene in L6 myotubes. ZLN005 increased PGC-1α mRNA levels in a dose-dependent manner; 20 μmol/L ZLN005 caused a threefold increase over the control after 24 h. At 10 μmol/L, the PGC-1α mRNA levels were increased to almost the same extent at 16 to 48 h [1]. ZLN005 did not increase the expression of the PGC-1α gene in rat primary hepatocytes. AMP-activated protein kinase is involved in the mechanism inducing PGC-1α in L6 myotubes [1]in vivo: An insulin tolerance test revealed that treatment with ZLN005 significantly decreased insulin resistance in db/db mice, as evidenced by the approximately 18% decrease in the AUC. A PTT also was performed in db/db mice, and ZLN005 improved pyruvate tolerance, as evidenced by the 16% decrease in the AUC. In db/db mice, plasma NEFA and triglyceride levels were decreased by 20% and 37%, respectively, and cholesterol was decreased by 10% with ZLN005 treatment. Plasma insulin and β-hydroxybutyrate content, liver/bodyweight index and adipose composition, and muscle and liver triglyceride levels, however, were not ameliorated by treatment with ZLN005 or metformin [1].

 Names

Name 2-(4-tert-butylphenyl)-1H-benzimidazole
Synonym More Synonyms

 ZLN005 Biological Activity

Description ZLN005 is a novel transcriptional regulator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α).IC50 value:Target: PGC-1αin vitro: ZLN005 increases expression of the PGC-1α gene in L6 myotubes. ZLN005 increased PGC-1α mRNA levels in a dose-dependent manner; 20 μmol/L ZLN005 caused a threefold increase over the control after 24 h. At 10 μmol/L, the PGC-1α mRNA levels were increased to almost the same extent at 16 to 48 h [1]. ZLN005 did not increase the expression of the PGC-1α gene in rat primary hepatocytes. AMP-activated protein kinase is involved in the mechanism inducing PGC-1α in L6 myotubes [1]in vivo: An insulin tolerance test revealed that treatment with ZLN005 significantly decreased insulin resistance in db/db mice, as evidenced by the approximately 18% decrease in the AUC. A PTT also was performed in db/db mice, and ZLN005 improved pyruvate tolerance, as evidenced by the 16% decrease in the AUC. In db/db mice, plasma NEFA and triglyceride levels were decreased by 20% and 37%, respectively, and cholesterol was decreased by 10% with ZLN005 treatment. Plasma insulin and β-hydroxybutyrate content, liver/bodyweight index and adipose composition, and muscle and liver triglyceride levels, however, were not ameliorated by treatment with ZLN005 or metformin [1].
Related Catalog
References

[1]. Zhang LN, et al. Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes. 2013 Apr;62(4):1297-307.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 415.3±38.0 °C at 760 mmHg
Melting Point 257-258℃
Molecular Formula C17H18N2
Molecular Weight 250.338
Flash Point 205.4±13.2 °C
Exact Mass 250.147003
PSA 28.68000
LogP 4.93
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.618

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H319-H413
Precautionary Statements P305 + P351 + P338
RIDADR NONH for all modes of transport

 Synthetic Route

p-t-Butylbenzaldehyde structure

p-t-Butylbenzal...

CAS#:939-97-9

o-Phenylenediamine structure

o-Phenylenediamine

CAS#:95-54-5

~80%

ZLN005 Structure

ZLN005

CAS#:49671-76-3

Literature: Du, Li-Hua; Luo, Xi-Ping Synthetic Communications, 2010 , vol. 40, # 19 p. 2880 - 2886
2-Chlorobenzimidazole structure

2-Chlorobenzimi...

CAS#:4857-06-1

4-tert-Butylphenylboronic acid structure

4-tert-Butylphe...

CAS#:123324-71-0

~99%

ZLN005 Structure

ZLN005

CAS#:49671-76-3

Literature: Duefert, M. Alexander; Billingsley, Kelvin L.; Buchwald, Stephen L. Journal of the American Chemical Society, 2013 , vol. 135, # 34 p. 12877 - 12885
(E)-N-(2-azidophenyl)-1-(4-(tert-butyl)phenyl)methanimine structure

(E)-N-(2-azidop...

CAS#:1042161-47-6

~%

ZLN005 Structure

ZLN005

CAS#:49671-76-3

Literature: Shen, Meihua; Driver, Tom G. Organic Letters, 2008 , vol. 10, # 15 p. 3367 - 3370

 Synonyms

2-(4-tert-butylphenyl)-1H-benzimidazole
2-[4-(2-Methyl-2-propanyl)phenyl]-1H-benzimidazole
2-(4-tert-Butylphenyl)-1H-benzimidazole 2-[4-(1,1-Dimethylethyl)phenyl]-1H-benzimidazole
1H-Benzimidazole, 2-[4-(1,1-dimethylethyl)phenyl]-
ZLN005
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Related Compounds: More...
ZLN005-d4
2410443-42-2
Chemsrc provides ZLN005(CAS#:49671-76-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of ZLN005 are included as well.>> amp version: ZLN005

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