Corticosterone

Modify Date: 2024-01-02 08:20:52

Corticosterone structure	Common Name	Corticosterone
	CAS Number	50-22-6	Molecular Weight	346.461
	Density	1.2±0.1 g/cm3	Boiling Point	529.2±50.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₃₀O₄	Melting Point	179-183 °C(lit.)
	MSDS	Chinese USA	Flash Point	288.0±26.6 °C
	Symbol	GHS07	Signal Word	Warning

Use of Corticosterone

Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.

Name	corticosterone
Synonym	More Synonyms

Description	Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Neurological Disease Natural Products >> Steroids
Target	Human Endogenous Metabolite
References	[1]. Gasser PJ, et al. Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: potential role for organiccation transporter 3 in stress-induced modulation of monoaminergic neurotransmission. J Neurosci. 2006 Aug 23;26(34):8758-8766.

Density	1.2±0.1 g/cm3
Boiling Point	529.2±50.0 °C at 760 mmHg
Melting Point	179-183 °C(lit.)
Molecular Formula	C₂₁H₃₀O₄
Molecular Weight	346.461
Flash Point	288.0±26.6 °C
Exact Mass	346.214417
PSA	74.60000
LogP	1.76
Vapour Pressure	0.0±3.2 mmHg at 25°C
Index of Refraction	1.576
Storage condition	Store at RT
Stability	Stable, but light sensitive. Incompatible with strong oxidizing agents.

Corticosterone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GM7650000

CHEMICAL NAME :: Corticosterone

CAS REGISTRY NUMBER :: 50-22-6

BEILSTEIN REFERENCE NO. :: 2339601

LAST UPDATED :: 199703

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C21-H30-O4

MOLECULAR WEIGHT :: 346.51

WISWESSER LINE NOTATION :: L E5 B666 OV MUTJ A1 CQ E1 FV1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 14 mg/kg

SEX/DURATION :: female 19-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - respiratory system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 525 mg/kg

SEX/DURATION :: female 12-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - endocrine system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 500 mg/kg

SEX/DURATION :: female 8-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 84 mg/kg

SEX/DURATION :: female 16-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1472 mg/kg

SEX/DURATION :: female 11-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 400 mg/kg

SEX/DURATION :: female 11-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 100 mg/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 400 mg/kg

SEX/DURATION :: female 11-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 40 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 80 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Bird - chicken Embryo

DOSE/DURATION :: 1500 pmol/L

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 257,804,1975

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H317
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xi,N,Xn,T
Risk Phrases	R43
Safety Phrases	S36
RIDADR	2811.0
WGK Germany	3
RTECS	GM7650000
Hazard Class	6.1

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CORTICOSTERONE

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EINECS 200-019-6

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11b,21-Dihydroxy-4-pregnene-3,20-dione

MFCD00037715

(11β)-11,21-Dihydroxypregn-4-ene-3,20-dione

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11b,21-Dihydroxyprogesterone

(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

(11b)-11,21-Dihydroxypregn-4-ene-3,20-dione

11b,21-Dihydroxypregn-4-ene-3,20-dione

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4-08-00-02907 (Beilstein Handbook Reference)

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Corticosterone

Use of Corticosterone

Names

Corticosterone Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

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