Ascorbic acid

Modify Date: 2024-04-12 10:48:10

Ascorbic acid Structure
Ascorbic acid structure
 Common Name Ascorbic acid
CAS Number 50-81-7 Molecular Weight 176.124
Density 2.0±0.1 g/cm3 Boiling Point 552.7±50.0 °C at 760 mmHg
Molecular Formula C6H8O6 Melting Point 190-194 °C (dec.)
MSDS Chinese USA Flash Point 238.2±23.6 °C

 Use of Ascorbic acid


L-Ascorbic acid is an effective reducing agent and donor antioxidant.

 Names

Name L-ascorbic acid
Synonym More Synonyms

 Ascorbic acid Biological Activity

Description L-Ascorbic acid is an effective reducing agent and donor antioxidant.
Related Catalog
References

[1]. Lachapelle MY, et al. Inactivation dates of the human and guinea pig vitamin C genes. Genetica. 2011 Feb;139(2):199-207.

 Chemical & Physical Properties

Density 2.0±0.1 g/cm3
Boiling Point 552.7±50.0 °C at 760 mmHg
Melting Point 190-194 °C (dec.)
Molecular Formula C6H8O6
Molecular Weight 176.124
Flash Point 238.2±23.6 °C
Exact Mass 176.032089
PSA 107.22000
LogP -2.41
Vapour Pressure 0.0±3.4 mmHg at 25°C
Index of Refraction 1.711
Water Solubility 333 g/L (20 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CI7650000
CHEMICAL NAME :
L-Ascorbic acid
CAS REGISTRY NUMBER :
50-81-7
LAST UPDATED :
199707
DATA ITEMS CITED :
46
MOLECULAR FORMULA :
C6-H8-O6
MOLECULAR WEIGHT :
176.14
WISWESSER LINE NOTATION :
T5OV EHJ CQ DQ EYQ1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
2300 mg/kg/2D
TOXIC EFFECTS :
Blood - oxidant related (GPD deficient) anemia
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
11900 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3367 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
643 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
518 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
546 gm/kg/13W-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2500 mg/kg
SEX/DURATION :
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
6680 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
800 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
19500 mg/kg
SEX/DURATION :
female 30-58 day(s) after conception lactating female 10 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5800 mg/kg
SEX/DURATION :
female 1-58 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2471 mg/kg
SEX/DURATION :
multigenerations
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
Sperm Morphology
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Mammal - species unspecified Lymphocyte
DOSE/DURATION :
500 umol/L
REFERENCE :
JNSVA5 Journal of Nutritional Science and Vitaminology. (Business Center for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.19- 1973- Volume(issue)/page/year: 24,263,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0462 No. of Facilities: 5030 (estimated) No. of Industries: 24 No. of Occupations: 33 No. of Employees: 69440 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0462 No. of Facilities: 7888 (estimated) No. of Industries: 41 No. of Occupations: 56 No. of Employees: 137698 (estimated) No. of Female Employees: 84231 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Risk Phrases R20/21/22
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS CI7650000
HS Code 29362700

 Synthetic Route

 Customs

HS Code 29362700

 Articles1808

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 Synonyms

(5R)-5-[(1S)-1,2-Dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one
L-Ascorbic acid
EINECS 200-066-2
L-Ascorbic acid（C)
(5R)-5-[(1S)-1,2-Dihydroxyethyl]-3,4-dihydroxy-2(5H)-furanone
Calscorbate
monodehydro-L-ascorbic acid
Cetebe
(5R)-5-[(1S)-1,2-Dihydroxyéthyl]-3,4-dihydroxy-2(5H)-furanone
MFCD03457784
L-Threoascorbic acid,Antiscorbutic factor,Vitamin C
L(+)-Ascorbic acid
(R)-5-((S)-1,2-Dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one
(5R)-5-[(1S)-1,2-Dihydroxyethyl]-3,4-dihydroxy-2(5H)-furanon
Vitamin C
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