Rhododendrol

Modify Date: 2024-01-02 12:20:26

Rhododendrol Structure
Rhododendrol structure
Common Name Rhododendrol
CAS Number 501-96-2 Molecular Weight 166.22
Density 1.1±0.1 g/cm3 Boiling Point 315.4±17.0 °C at 760 mmHg
Molecular Formula C10H14O2 Melting Point N/A
MSDS Chinese USA Flash Point 153.4±15.5 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Rhododendrol


Rhododendrol can induce leukoderma. Rhododendrol induces generation of hydroxyl radicals and melanocyte cytotoxicity by increasing glutathione levels. Rhododendrol is a phenolic compound that can be isolated from plants such as Acer nikoense and Betula platyphylla[1].

 Names

Name 4-[(3R)-3-Hydroxybutyl]phenol
Synonym More Synonyms

 Rhododendrol Biological Activity

Description Rhododendrol can induce leukoderma. Rhododendrol induces generation of hydroxyl radicals and melanocyte cytotoxicity by increasing glutathione levels. Rhododendrol is a phenolic compound that can be isolated from plants such as Acer nikoense and Betula platyphylla[1].
Related Catalog
References

[1]. Gabe Y, et al. Substantial evidence for the rhododendrol-induced generation of hydroxyl radicals that causes melanocyte cytotoxicity and induces chemical leukoderma. J Dermatol Sci. 2018 Sep;91(3):311-316.  

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 315.4±17.0 °C at 760 mmHg
Molecular Formula C10H14O2
Molecular Weight 166.22
Flash Point 153.4±15.5 °C
Exact Mass 166.099380
PSA 40.46000
LogP 1.49
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.552
Storage condition ?20°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H319
Precautionary Statements P305 + P351 + P338
Hazard Codes Xn
Risk Phrases 22-36
Safety Phrases 26
RIDADR NONH for all modes of transport

 Articles2

More Articles
T-Cell Responses to Tyrosinase-Derived Self-Peptides in Patients with Leukoderma Induced by Rhododendrol: Implications for Immunotherapy Targeting Melanoma.

Dermatology 232 , 44-9, (2016)

Rhododendrol, a phenolic compound contained in lightening/whitening cosmetics, can bind and inhibit tyrosinase and was reported to induce leukoderma in Japan. Only 2% of the cosmetics users are affect...

Rhododendrol, a depigmentation-inducing phenolic compound, exerts melanocyte cytotoxicity via a tyrosinase-dependent mechanism.

Pigment Cell Melanoma Res. 27(5) , 754-63, (2014)

Rhododendrol, an inhibitor of melanin synthesis developed for lightening/whitening cosmetics, was recently reported to induce a depigmentary disorder principally at the sites of repeated chemical cont...

 Synonyms

4-[(3R)-3-Hydroxybutyl]phenol
Benzenepropanol, 4-hydroxy-α-methyl-
4-(3-Hydroxybutyl)phenol
4-(p-Hydroxyphenyl)-2-butanol
Benzenepropanol, 4-hydroxy-α-methyl-, (R)-
Benzenepropanol, 4-hydroxy-α-methyl-, (αR)-
2-Butanol, 4-(p-hydroxyphenyl)-
UNII:12QWN45UL0
Rhododendrol
(-)-Rhododendrol
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